MetaCyc Pathway: superpathway of microbial D-galacturonate and D-glucuronate degradation in Echinicola vietnamensis KMM 6221, DSM 17526

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Reactions and Genes L-tyrosine (N)
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Beta-glucuronidase:
a β-D-glucuronide + H2O→D-glucopyranuronate + an alcohol
(EC 3.2.1.31)
No genes
Galactarate dehydratase:
galactarate→5-dehydro-4-deoxy-D-glucarate + H2O
(EC 4.2.1.42)
No genes
Glucarate dehydratase:
D-glucarate→5-dehydro-4-deoxy-D-glucarate + H2O
(EC 4.2.1.40)
No genes
Uronate dehydrogenase:
β-D-glucuronate + NAD+→D-glucaro-1,5-lactone + NADH + H+
(EC 1.1.1.203)
No genes
D-galactopyranuronate→aldehydo-D-galacturonate (spontaneous)
No genes
4-deoxy-L-threo-hex-4-enopyranuronate→5-dehydro-4-deoxy-D-glucuronate (EC 4.2.99.25)
No genes
Uronate dehydrogenase:
β-D-galacturonate + NAD+→D-galactaro-1,5-lactone + NADH + H+
(EC 1.1.1.203)
No genes
4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase:
5-dehydro-4-deoxy-D-glucuronate→3-deoxy-D-glycero-2,5-hexodiulosonate
(EC 5.3.1.17)
Echvi_4006 -0.4
Glucuronate isomerase:
aldehydo-D-galacturonate→D-tagaturonate
(EC 5.3.1.12)
Echvi_3072 -0.9
Echvi_3102 +0.4
2-dehydro-3-deoxyglucarate aldolase:
5-dehydro-4-deoxy-D-glucarate→(2R)-tartronate semialdehyde + pyruvate
(EC 4.1.2.20)
No genes
aldehydo-D-galacturonate + NADPH + H+→L-galactonate + NADP+ (EC 1.1.1.365)
No genes
D-glucopyranuronate→aldehydo-D-glucuronate (spontaneous)
No genes
D-galactaro-1,5-lactone→D-galactaro-1,4-lactone (EC 5.4.1.4)
No genes
D-glucaro-1,5-lactone→D-glucaro-1,4-lactone (spontaneous) (EC 5.4.1.4)
No genes
2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase (in reverse):
3-deoxy-D-glycero-2,5-hexodiulosonate + NADH + H+→2-dehydro-3-deoxy-D-gluconate + NAD+
(EC 1.1.1.127)
Echvi_4005 -0.2
Tagaturonate reductase (in reverse):
D-tagaturonate + NADH + H+→D-altronate + NAD+
(EC 1.1.1.58)
Echvi_3071 -0.7
Glucuronate isomerase:
aldehydo-D-glucuronate→D-fructuronate
(EC 5.3.1.12)
Echvi_3072 -0.9
Echvi_3102 +0.4
L-galactonate→2-dehydro-3-deoxy-L-galactonate + H2O (EC 4.2.1.146)
No genes
D-galactaro-1,4-lactone→5-dehydro-4-deoxy-D-glucarate + H+ (EC 5.5.1.27)
No genes
D-glucaro-1,4-lactone→5-dehydro-4-deoxy-D-glucarate + H+ (EC 5.5.1.27)
No genes
2-hydroxy-3-oxopropionate reductase (in reverse):
(2R)-tartronate semialdehyde + NAD(P)H + H+→D-glycerate + NAD(P)+
(EC 1.1.1.60)
No genes
5-dehydro-4-deoxyglucarate dehydratase:
5-dehydro-4-deoxy-D-glucarate + H+→2,5-dioxopentanoate + CO2 + H2O
(EC 4.2.1.41)
No genes
Altronate dehydratase:
D-altronate→2-dehydro-3-deoxy-D-gluconate + H2O
(EC 4.2.1.7)
Echvi_3632 -0.2
D-glycerate + ATP→2-phospho-D-glycerate + ADP + H+ (EC 2.7.1.165)
No genes
Fructuronate reductase (in reverse):
D-fructuronate + NADH + H+→D-mannonate + NAD+
(EC 1.1.1.57)
Echvi_3101 +0.8
2-dehydro-3-deoxy-L-galactonate→L-glyceraldehyde + pyruvate (EC 4.1.2.54)
No genes
2,5-dioxovalerate dehydrogenase:
2,5-dioxopentanoate + NADP+ + H2O→2-oxoglutarate + NADPH + 2 H+
(EC 1.2.1.26)
Echvi_3952 +0.8
Mannonate dehydratase:
D-mannonate→2-dehydro-3-deoxy-D-gluconate + H2O
(EC 4.2.1.8)
Echvi_1869 +1.3
Echvi_3100 -0.3
L-glyceraldehyde + NADPH + H+→glycerol + NADP+ (EC 1.1.1.372)
No genes
2-dehydro-3-deoxy-D-gluconate + ATP→2-dehydro-3-deoxy-D-gluconate 6-phosphate + ADP + H+ (EC 2.7.1.178; 2.7.1.45)
Echvi_3631 +0.2
2-dehydro-3-deoxy-phosphogluconate aldolase:
2-dehydro-3-deoxy-D-gluconate 6-phosphate→D-glyceraldehyde 3-phosphate + pyruvate
(EC 4.1.2.14; 4.1.2.55)
Echvi_3630 -1.6
Echvi_3770 -0.1

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information