MetaCyc Pathway: 4-hydroxy-2-nonenal detoxification in Pseudomonas simiae WCS417

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Reactions and Genes methylglyoxal 0.032 vol%
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Glutathione transferase:
4-hydroxy-2-nonenal + glutathione→(glutathion-S-yl)-4-hydroxy-2-nonenal (EC 2.5.1.18)
PS417_06435 +0.3
PS417_10480 -0.3
PS417_11050 N.D.
PS417_11065 +0.5
PS417_15405 -0.0
PS417_16460 +0.2
PS417_17970 -0.4
PS417_18815 -0.2
PS417_19380 -1.8
PS417_21950 N.D.
PS417_22000 -0.1
PS417_22030 +0.6
PS417_27545 +0.3
PS417_04995 -0.1
PS417_05025 +0.2
(glutathion-S-yl)-4-hydroxy-2-nonenal + H2O→S-(4-hydroxy-nonenal-3-yl)-L-cysteinylglycine + L-glutamate (EC 3.4.19.13)
No genes
S-(4-hydroxy-nonenal-3-yl)-L-cysteinylglycine + H2O→S-(4-hydroxy-nonenal-3-yl)-L-cysteine + glycine (EC 3.4.13.23)
No genes
Cysteine-S-conjugate N-acetyltransferase:
S-(4-hydroxy-nonenal-3-yl)-L-cysteine + acetyl-CoA→4-hydroxy-2-nonenal-N-acetyl-L-cysteine + coenzyme A + H+ (EC 2.3.1.80)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information