MetaCyc Pathway: glutathione-mediated detoxification I in Pseudomonas simiae WCS417

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Reactions and Genes methylglyoxal 0.032 vol%
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Glutathione transferase:
RX + glutathione→a glutathione-S-conjugate + HX (EC 2.5.1.18)
PS417_06435 +0.3
PS417_10480 -0.3
PS417_11050 N.D.
PS417_11065 +0.5
PS417_15405 -0.0
PS417_16460 +0.2
PS417_17970 -0.4
PS417_18815 -0.2
PS417_19380 -1.8
PS417_21950 N.D.
PS417_22000 -0.1
PS417_22030 +0.6
PS417_27545 +0.3
PS417_04995 -0.1
PS417_05025 +0.2
a glutathione-S-conjugate[in] + ATP[in] + H2O[in]→a glutathione-S-conjugate[out] + ADP[in] + H+[in] + phosphate[in] (EC 7.6.2.3)
No genes
a glutathione-S-conjugate + H2O→an (L-cysteinylglycine)-S-conjugate + L-glutamate (EC 3.4.19.13)
No genes
an (L-cysteinylglycine)-S-conjugate + H2O→an L-cysteine-S-conjugate + glycine (EC 3.4.13.23)
No genes
Cysteine-S-conjugate N-acetyltransferase:
an L-cysteine-S-conjugate + acetyl-CoA→a mercapturate + coenzyme A + H+ (EC 2.3.1.80)
No genes
Cysteine-S-conjugate beta-lyase:
an L-cysteine-S-conjugate→2-aminoprop-2-enoate + a thiol (EC 4.4.1.13)
No genes
Tryptophanase:
2-aminoprop-2-enoate→2-iminopropanoate (spontaneous) (EC 4.1.99.1; 4.1.99.2; 4.3.1.13; 4.3.1.17; 4.3.1.18; 4.3.3.8; 4.4.1.1; 4.4.1.13; 4.4.1.15; 4.4.1.25; 4.4.1.28; 4.4.1.35; 4.5.1.2)
PS417_05075 +0.2
PS417_01110 -0.2
PS417_12125 +0.5
PS417_22365 -0.2
PS417_26310 -0.5
2-iminopropanoate + H2O→pyruvate + ammonium (spontaneous) (EC 3.5.99.10; 4.1.99.1; 4.1.99.2; 4.3.1.13; 4.3.1.17; 4.3.1.18; 4.3.3.8; 4.4.1.1; 4.4.1.13; 4.4.1.15; 4.4.1.25; 4.4.1.28; 4.4.1.35; 4.5.1.2)
PS417_05075 +0.2
PS417_01110 -0.2
PS417_12125 +0.5
PS417_22365 -0.2
PS417_26310 -0.5
PS417_27835 +1.4

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information