MetaCyc Pathway: superpathway of methylglyoxal degradation in Pseudomonas simiae WCS417

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Reactions and Genes methylglyoxal 0.032 vol%
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Methylglyoxal reductase (NADPH-dependent) (in reverse):
methylglyoxal + NADPH + H+→(S)-lactaldehyde + NADP+ (EC 1.1.1.283)
No genes
Lactoylglutathione lyase (in reverse):
methylglyoxal + glutathione→(R)-S-lactoylglutathione (EC 4.4.1.5)
PS417_14035 -6.8
Aldehyde reductase (in reverse):
methylglyoxal + NADPH + H+→hydroxyacetone + NADP+ (EC 1.1.1.21)
PS417_10670 +0.1
PS417_01130 -0.2
PS417_15340 -0.1
Hydroxyacylglutathione hydrolase:
(R)-S-lactoylglutathione + H2O→(R)-lactate + glutathione + H+ (EC 3.1.2.6)
PS417_06335 -0.9
PS417_12220 -4.8
PS417_20675 -0.0
Lactaldehyde dehydrogenase:
(S)-lactaldehyde + NAD+ + H2O→(S)-lactate + NADH + 2 H+ (EC 1.2.1.22)
No genes
hydroxyacetone + NADH + H+→(S)-propane-1,2-diol + NAD+
No genes
(S)-lactate[in] + an electron-transfer quinone→pyruvate[in] + an electron-transfer quinol (EC 1.1.5.M6)
PS417_15625 +0.4
PS417_19130 -0.0
(R)-lactate[in] + an electron-transfer quinone→pyruvate[in] + an electron-transfer quinol (EC 1.1.5.12)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information