MetaCyc Pathway: mevalonate pathway II (haloarchaea) in Echinicola vietnamensis KMM 6221, DSM 17526

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Reactions and Genes L-Leucine (N)
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Acetyl-CoA C-acyltransferase:
2 acetyl-CoA→acetoacetyl-CoA + coenzyme A (EC 2.3.1.16; 2.3.1.9)
Echvi_1071 -0.0
Echvi_3705 +1.4
Hydroxymethylglutaryl-CoA synthase:
acetoacetyl-CoA + acetyl-CoA + H2O→(S)-3-hydroxy-3-methylglutaryl-CoA + coenzyme A + H+ (EC 2.3.3.10)
No genes
Hydroxymethylglutaryl-CoA reductase (NADPH) (in reverse):
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+→(R)-mevalonate + coenzyme A + 2 NADP+ (EC 1.1.1.34)
No genes
Mevalonate kinase:
(R)-mevalonate + ATP→(R)-5-phosphomevalonate + ADP + H+ (EC 2.7.1.36)
No genes
(R)-5-phosphomevalonate + ATP→3-methylbut-3-en-1-yl phosphate + ADP + CO2 + phosphate (EC 4.1.1.99)
No genes
3-methylbut-3-en-1-yl phosphate + ATP→3-methylbut-3-en-1-yl diphosphate + ADP (EC 2.7.4.26)
No genes
Isopentenyl-diphosphate Delta-isomerase:
3-methylbut-3-en-1-yl diphosphate→prenyl diphosphate (EC 5.3.3.2)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information