MetaCyc Pathway: dTDP-β-L-mycarose biosynthesis in Echinicola vietnamensis KMM 6221, DSM 17526

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Reactions and Genes L-Lysine (N)
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Glucose-1-phosphate thymidylyltransferase:
α-D-glucopyranose 1-phosphate + H+ + dTTP→dTDP-α-D-glucose + diphosphate (EC 2.7.7.24)
Echvi_1740 N.D.
Echvi_2361 N.D.
dTDP-glucose 4,6-dehydratase:
dTDP-α-D-glucose→dTDP-4-dehydro-6-deoxy-α-D-glucopyranose + H2O (EC 4.2.1.46)
Echvi_2328 -1.5
Echvi_2329 N.D.
Echvi_3799 -0.5
Echvi_3804 +0.7
dTDP-4-dehydro-6-deoxy-α-D-glucopyranose→dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose + H+ + H2O (EC 4.2.1.159)
No genes
dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose + NAD(P)H + 2 H+→dTDP-4-dehydro-2,6-dideoxy-α-D-allose + NAD(P)+
No genes
dTDP-4-dehydro-2,6-dideoxy-α-D-allose + S-adenosyl-L-methionine→dTDP-4-dehydro-3-C-methyl-2,6-dideoxy-β-L-allose + S-adenosyl-L-homocysteine + H+
No genes
dTDP-4-dehydro-3-C-methyl-2,6-dideoxy-β-L-allose→dTDP-4-dehydro-3-C-methyl-2,6-dideoxy-β-L-galactose
No genes
dTDP-4-dehydro-3-C-methyl-2,6-dideoxy-β-L-galactose + NADPH + H+→dTDP-β-L-mycarose + NADP+
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information