MetaCyc Pathway: 2-allylmalonyl-CoA biosynthesis in Agrobacterium fabrum C58

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Reactions and Genes 6-aminocaproic (N)
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propanoyl-CoA + TcsB polyketide synthase→propanoyl-[TcsB polyketide synthase] + coenzyme A
No genes
malonyl-CoA + TcsA polyketide synthase→malonyl-[TcsA polyketide synthase] + coenzyme A
No genes
malonyl-[TcsA polyketide synthase] + propanoyl-[TcsB polyketide synthase] + H+→3-oxopentanoyl-[TcsA polyketide synthase] + CO2 + TcsB polyketide synthase
No genes
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
3-oxopentanoyl-[TcsA polyketide synthase] + NADPH + H+→(3R)-3-hydroxypentanoyl-[TcsA polyketide synthase] + NADP+ (EC 1.1.1.100)
Atu0705 +0.1
Atu0990 -0.0
Atu1095 N.D.
Atu1255 +0.0
Atu1338 +0.1
Atu2042 +0.2
Atu3051 -0.0
Atu3074 -0.2
Atu3333 -0.0
Atu3531 +0.1
Atu3813 -0.1
Atu4220 -0.1
Atu4325 -0.1
Atu4595 -0.1
Atu4821 -0.1
Atu4877 -0.1
Atu5122 +1.7
Atu5214 N.D.
Atu5250 N.D.
Atu5438 +0.1
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
(3R)-3-hydroxypentanoyl-[TcsA polyketide synthase]→(2E)-pent-2-enoyl-[TcsA polyketide synthase] + H2O (EC 4.2.1.59)
Atu0151 N.D.
Atu1383 N.D.
Atu1599 N.D.
(2E)-pent-2-enoyl-[TcsA polyketide synthase] + CO2 + NADPH→2-carboxypentanoyl-[TcsA polyketide synthase] + NADP+
No genes
2-carboxypentanoyl-[TcsA polyketide synthase] + FAD + H+→2-allylmalonyl-[TcsA polyketide synthase] + FADH2
No genes
2-allylmalonyl-[TcsA polyketide synthase] + coenzyme A→2-allylmalonyl-CoA + TcsA polyketide synthase
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information