MetaCyc Pathway: aromatic compounds degradation via β-ketoadipate in Pseudomonas simiae WCS417

Add experiment(s):


Reactions and Genes L-Tryptophan (C)
remove
Catechol 1,2-dioxygenase:
catechol + dioxygencis,cis-muconate + 2 H+
(EC 1.13.11.1)
PS417_23660 -3.1
Protocatechuate 3,4-dioxygenase:
protocatechuate + dioxygen→3-carboxy-cis,cis-muconate + 2 H+
(EC 1.13.11.3)
PS417_06715 -0.1
PS417_06720 -0.9
3-carboxy-cis,cis-muconate cycloisomerase (in reverse):
3-carboxy-cis,cis-muconate + H+→(2-carboxy-2,5-dihydro-5-oxofuran-2-yl)-acetate
(EC 5.5.1.2)
PS417_06730 -1.1
PS417_11635 N.D.
Muconate cycloisomerase (in reverse):
cis,cis-muconate + H+→(+)-muconolactone
(EC 5.5.1.1)
PS417_23670 -2.8
4-carboxymuconolactone decarboxylase:
(2-carboxy-2,5-dihydro-5-oxofuran-2-yl)-acetate + H+→(4,5-dihydro-5-oxofuran-2-yl)-acetate + CO2
(EC 4.1.1.44)
PS417_06740 N.D.
PS417_04220 -0.4
Muconolactone Delta-isomerase:
(+)-muconolactone→(4,5-dihydro-5-oxofuran-2-yl)-acetate
(EC 5.3.3.4)
PS417_23665 -4.0
3-oxoadipate enol-lactonase:
(4,5-dihydro-5-oxofuran-2-yl)-acetate + H2O→3-oxoadipate + H+
(EC 3.1.1.24)
PS417_06735 -2.1
PS417_09080 -0.1
PS417_15225 -0.7
PS417_20530 +0.1
3-oxoadipate CoA-transferase:
3-oxoadipate + succinyl-CoA→3-oxoadipoyl-CoA + succinate
(EC 2.8.3.6)
PS417_06700 -3.8
PS417_06705 -3.2
3-oxoadipyl-CoA thiolase (in reverse):
3-oxoadipoyl-CoA + coenzyme A→acetyl-CoA + succinyl-CoA
(EC 2.3.1.174)
PS417_06710 -4.6

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information