MetaCyc Pathway: propanoate fermentation to 2-methylbutanoate in Pseudomonas simiae WCS417

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Reactions and Genes L-Isoleucine (C)
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Propionate CoA-transferase:
propanoate + acetyl-CoA→acetate + propanoyl-CoA (EC 2.8.3.1)
No genes
Acetyl-CoA C-acyltransferase:
propanoyl-CoA + acetyl-CoA→2-methylacetoacetyl-CoA + coenzyme A (EC 2.3.1.16)
PS417_06710 -0.9
PS417_07580 N.D.
PS417_10515 -0.2
PS417_13855 -4.5
PS417_15175 N.D.
PS417_19210 -0.1
PS417_21220 +0.3
PS417_03145 -0.3
3-hydroxy-2-methylbutyryl-CoA dehydrogenase (in reverse):
2-methylacetoacetyl-CoA + NADH + H+→(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD+ (EC 1.1.1.178)
PS417_07575 +0.3
PS417_13860 N.D.
PS417_21215 -0.0
(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA→(E)-2-methylcrotonoyl-CoA + H2O (EC 4.2.1.150)
PS417_07030 +0.2
PS417_07575 +0.3
PS417_08535 +0.3
PS417_10680 +0.1
PS417_11445 -0.8
PS417_21215 -0.0
PS417_22625 +0.1
(E)-2-methylcrotonoyl-CoA + a reduced electron-transfer flavoprotein→(2S)-2-methylbutanoyl-CoA + an oxidized electron-transfer flavoprotein + H+ (EC 1.3.8.5)
PS417_13840 -0.4
PS417_13850 -5.7
(2S)-2-methylbutanoyl-CoA + H2O→2-methylbutanoate + coenzyme A + H+
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information