| Reactions and Genes | C.elegans, mixed culture-1 |
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| remove |
Saccharopine dehydrogenase (NADP(+), L-lysine-forming) (in reverse):
L-lysine + 2-oxoglutarate + NADPH + H+→L-saccharopine + NADP+ + H2O (EC 1.5.1.8) |
| No genes |
L-lysine 6-transaminase:
L-lysine + 2-oxoglutarate→(S)-2-amino-6-oxohexanoate + L-glutamate (EC 2.6.1.36) |
| No genes |
L-lysine oxidase:
L-lysine + dioxygen + H2O→6-amino-2-oxohexanoate + ammonium + hydrogen peroxide (EC 1.4.3.14) |
| No genes |
| L-lysine + acetyl-CoA→N6-acetyl-L-lysine + coenzyme A + H+ (EC 2.3.1.306) |
| No genes |
Lysine decarboxylase:
L-lysine + H+→cadaverine + CO2 (EC 4.1.1.18) |
| PP_0864 | +0.2 |
| PP_4140 | -0.1 |
Lysine--pyruvate 6-transaminase:
L-lysine + pyruvate→(S)-2-amino-6-oxohexanoate + L-alanine (EC 2.6.1.71) |
| No genes |
Lysine 2-monooxygenase:
L-lysine + dioxygen→5-aminopentanamide + CO2 + H2O (EC 1.13.12.2) |
| PP_0383 | +0.3 |
Lysine 2,3-aminomutase:
L-lysine→L-β-lysine (EC 5.4.3.2) |
| No genes |
Amino-acid racemase:
L-lysine→D-lysine (EC 5.1.1.10; 5.1.1.5) |
| PP_3722 | +1.1 |
Lysine 6-dehydrogenase:
L-lysine + NAD+ + H2O→(S)-2-amino-6-oxohexanoate + ammonium + NADH + H+ (EC 1.4.1.18) |
| No genes |
Saccharopine dehydrogenase (NAD(+), L-glutamate-forming):
L-saccharopine + NAD+ + H2O→(S)-2-amino-6-oxohexanoate + L-glutamate + NADH + H+ (EC 1.5.1.9) |
| No genes |
5-aminopentanamidase:
5-aminopentanamide + H2O→5-aminopentanoate + ammonium (EC 3.5.1.30) |
| PP_0382 | +0.1 |
| N6-acetyl-L-lysine + 2-oxoglutarate→2-keto-6-acetamidocaproate + L-glutamate |
| No genes |
Beta-lysine 5,6-aminomutase:
L-β-lysine→(3S,5S)-3,5-diaminohexanoate (EC 5.4.3.3) |
| No genes |
D-amino-acid oxidase:
D-lysine + dioxygen + H2O→6-amino-2-oxohexanoate + ammonium + hydrogen peroxide (EC 1.4.3.3) |
| PP_3596 | -1.6 |
L-aminoadipate-semialdehyde dehydrogenase:
(S)-2-amino-6-oxohexanoate→1-piperideine 6-carboxylate + H+ + H2O (spontaneous) (EC 1.2.1.31; 1.4.1.18) |
| PP_2563 | -0.2 |
| 6-amino-2-oxohexanoate + hydrogen peroxide→5-aminopentanoate + CO2 + H2O (spontaneous) |
| No genes |
Putrescine aminotransferase:
cadaverine + 2-oxoglutarate→5-aminopentanal + L-glutamate (EC 2.6.1.82) |
| No genes |
L-aminoadipate-semialdehyde dehydrogenase:
(S)-2-amino-6-oxohexanoate + NAD(P)+ + H2O→L-2-aminoadipate + NAD(P)H + 2 H+ (EC 1.2.1.31) |
| PP_2563 | -0.2 |
L-erythro-3,5-diaminohexanoate dehydrogenase:
(3S,5S)-3,5-diaminohexanoate + NAD+ + H2O→(S)-5-amino-3-oxohexanoate + ammonium + NADH + H+ (EC 1.4.1.11) |
| No genes |
| 2-keto-6-acetamidocaproate + NAD+ + H2O→5-acetamidovalerate + CO2 + NADH + H+ |
| No genes |
| 6-amino-2-oxohexanoate→1-piperideine-2-carboxylate + H+ + H2O (spontaneous) |
| No genes |
Aminobutyraldehyde dehydrogenase:
5-aminopentanal + NAD+ + H2O→5-aminopentanoate + NADH + 2 H+ (EC 1.2.1.19) |
| PP_1481 | +0.3 |
| PP_2801 | +0.0 |
| 5-acetamidovalerate + H2O→5-aminopentanoate + acetate |
| No genes |
| (S)-5-amino-3-oxohexanoate + acetyl-CoA→acetoacetate + (S)-3-aminobutanoyl-CoA (EC 2.3.1.247) |
| No genes |
Pyrroline-2-carboxylate reductase (in reverse):
1-piperideine-2-carboxylate + NAD(P)H + 2 H+→L-pipecolate + NAD(P)+ (EC 1.5.1.1) |
| PP_3591 | -1.2 |
3-aminobutyryl-CoA ammonia-lyase:
(S)-3-aminobutanoyl-CoA→crotonyl-CoA + ammonium (EC 4.3.1.14) |
| No genes |
L-pipecolate oxidase:
L-pipecolate + dioxygen→1-piperideine 6-carboxylate + hydrogen peroxide + H+ (EC 1.5.3.7) |
| PP_5257 | -1.7 |
5-aminovalerate transaminase:
5-aminopentanoate + 2-oxoglutarate→glutarate semialdehyde + L-glutamate (EC 2.6.1.48) |
| PP_0214 | -1.5 |
| crotonyl-CoA[cytosol] + 2 NADH[cytosol] + 2 an oxidized ferredoxin [iron-sulfur] cluster[cytosol]→butanoyl-CoA[cytosol] + 2 NAD+[cytosol] + 2 a reduced ferredoxin [iron-sulfur] cluster[cytosol] (EC 1.3.1.109) |
| No genes |
L-aminoadipate-semialdehyde dehydrogenase:
1-piperideine 6-carboxylate + NAD+ + 2 H2O→L-2-aminoadipate + NADH + H+ (EC 1.2.1.31) |
| PP_2563 | -0.2 |
Glutarate-semialdehyde dehydrogenase:
glutarate semialdehyde + NADP+ + H2O→glutarate + NADPH + 2 H+ (EC 1.2.1.20) |
| PP_0213 | +0.1 |
| PP_3151 | +0.1 |
| PP_4422 | +0.8 |
2-aminoadipate transaminase:
L-2-aminoadipate + 2-oxoglutarate→2-oxoadipate + L-glutamate (EC 2.6.1.39) |
| PP_4108 | +0.3 |
Butyrate--acetoacetate CoA-transferase:
acetoacetate + butanoyl-CoA→acetoacetyl-CoA + butanoate (EC 2.8.3.9) |
| No genes |
Succinate--hydroxymethylglutarate CoA-transferase:
glutarate + succinyl-CoA→glutaryl-CoA + succinate (EC 2.8.3.13) |
| PP_0159 | -0.5 |
| 2-oxoglutarate + glutarate + dioxygen→(S)-2-hydroxyglutarate + CO2 + succinate (EC 1.14.11.64) |
| PP_2909 | +0.3 |
| 2-oxoadipate + coenzyme A + NAD+→glutaryl-CoA + CO2 + NADH (EC 1.2.1.105) |
| No genes |
Acetyl-CoA C-acyltransferase (in reverse):
acetoacetyl-CoA + coenzyme A→2 acetyl-CoA (EC 2.3.1.16; 2.3.1.9) |
| PP_0582 | -0.1 |
| PP_1377 | -0.4 |
| PP_2051 | -0.0 |
| PP_2137 | +0.7 |
| PP_2215 | -1.9 |
| PP_3280 | -0.1 |
| PP_3355 | -0.1 |
| PP_3754 | +0.2 |
| PP_4636 | +0.0 |
| 2-oxoadipate + dioxygen→(R)-2-hydroxyglutarate + CO2 (EC 1.13.11.93) |
| PP_5260 | -0.8 |
| (S)-2-hydroxyglutarate + an electron-transfer quinone→2-oxoglutarate + an electron-transfer quinol (EC 1.1.5.13) |
| No genes |
Phosphate acetyltransferase:
acetyl-CoA + phosphate→acetyl phosphate + coenzyme A (EC 2.3.1.8) |
| PP_0774 | +0.0 |
| (R)-2-hydroxyglutarate + an oxidized electron carrier→2-oxoglutarate + a reduced two electron carrier (EC 1.1.99.39) |
| PP_4493 | -0.1 |
Acetate kinase (in reverse):
acetyl phosphate + ADP→acetate + ATP (EC 2.7.2.1; 2.7.2.15) |
| PP_1457 | -0.3 |
Links:
Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information