MetaCyc Pathway: superpathway of L-threonine biosynthesis in Dickeya dianthicola ME23

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Reactions and Genes Stem-Upstate
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Aspartate transaminase (in reverse):
oxaloacetate + L-glutamate→L-aspartate + 2-oxoglutarate (EC 2.6.1.1)
DZA65_RS01185 +0.1
DZA65_RS03780 -0.0
DZA65_RS07480 -0.2
DZA65_RS13450 +0.1
DZA65_RS14720 -0.0
DZA65_RS14995 +0.3
DZA65_RS19800 -0.0
Aspartate kinase:
L-aspartate + ATP→L-aspartyl-4-phosphate + ADP (EC 2.7.2.4)
DZA65_RS19485 -0.6
DZA65_RS20225 -1.7
DZA65_RS21465 +0.3
Aspartate-semialdehyde dehydrogenase (in reverse):
L-aspartyl-4-phosphate + NADPH + H+→L-aspartate 4-semialdehyde + NADP+ + phosphate (EC 1.2.1.11)
DZA65_RS15375 -0.5
DZA65_RS20950 N.D.
Homoserine dehydrogenase (in reverse):
L-aspartate 4-semialdehyde + NAD(P)H + H+→L-homoserine + NAD(P)+ (EC 1.1.1.3)
DZA65_RS19485 -0.6
DZA65_RS21465 +0.3
Homoserine kinase:
L-homoserine + ATP→O-phospho-L-homoserine + ADP + H+ (EC 2.7.1.39)
DZA65_RS19480 -1.7
Threonine synthase:
O-phospho-L-homoserine + H2O→L-threonine + phosphate (EC 4.2.3.1)
DZA65_RS19475 -1.0

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information