MetaCyc Pathway: superpathway of L-phenylalanine biosynthesis in Escherichia coli ECOR38

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Reactions and Genes Sodium-DL-Lactate
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3-deoxy-7-phosphoheptulonate synthase:
D-erythrose 4-phosphate + phosphoenolpyruvate + H2O→3-deoxy-D-arabino-heptulosonate 7-phosphate + phosphate (EC 2.5.1.54)
HEPCGN_01535 (aroG) -0.1
HEPCGN_05500 (aroH) +0.1
HEPCGN_20335 (aroF) -1.3
3-dehydroquinate synthase:
3-deoxy-D-arabino-heptulosonate 7-phosphate→3-dehydroquinate + phosphate (EC 4.2.3.4)
HEPCGN_15935 (aroB) -7.7
3-dehydroquinate dehydratase:
3-dehydroquinate→3-dehydroshikimate + H2O (EC 4.2.1.10)
HEPCGN_05580 (aroD) -6.6
HEPCGN_19525 (eno) N.D.
Shikimate dehydrogenase (in reverse):
3-dehydroshikimate + NADPH + H+→shikimate + NADP+ (EC 1.1.1.25)
HEPCGN_05585 (ydiB) +0.0
HEPCGN_11860 -0.1
HEPCGN_16385 (aroE) -5.2
Shikimate kinase:
shikimate + ATP→shikimate 3-phosphate + ADP + H+ (EC 2.7.1.71)
HEPCGN_07240 (aroL) -0.5
HEPCGN_15930 (aroK) -1.2
3-phosphoshikimate 1-carboxyvinyltransferase:
shikimate 3-phosphate + phosphoenolpyruvate→5-enolpyruvoyl-shikimate 3-phosphate + phosphate (EC 2.5.1.19)
HEPCGN_23035 (aroA) -4.8
Chorismate synthase:
5-enolpyruvoyl-shikimate 3-phosphate→chorismate + phosphate (EC 4.2.3.5)
HEPCGN_21820 (aroC) -8.0
Chorismate mutase:
chorismate→prephenate (EC 5.4.99.5)
HEPCGN_20340 (tyrA) -4.1
HEPCGN_20345 (pheA) -3.1
Prephenate dehydratase:
prephenate + H+→3-phenyl-2-oxopropanoate + CO2 + H2O (EC 4.2.1.51)
HEPCGN_20345 (pheA) -3.1
Aspartate transaminase (in reverse):
3-phenyl-2-oxopropanoate + L-glutamate→L-phenylalanine + 2-oxoglutarate (EC 2.6.1.1; 2.6.1.27; 2.6.1.57)
HEPCGN_03215 (hisC) -5.8
HEPCGN_11535 (tyrB) -0.4
HEPCGN_13355 (ilvE) -5.6
HEPCGN_14250 +0.1
HEPCGN_20050 (aRO8) -0.0
HEPCGN_23140 (aspC) +0.1
HEPCGN_26230 (ydcR) -0.4

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information