MetaCyc Pathway: superpathway of N-acetylneuraminate degradation in Escherichia coli ECOR38

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Reactions and Genes Sodium-DL-Lactate
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N-acetyl-β-neuraminate→aceneuramate (EC 5.1.3.24)
HEPCGN_16745 (nanQ) -0.3
N-acetylneuraminate lyase:
aceneuramate→N-acetyl-D-mannosamine + pyruvate (EC 4.1.3.3)
HEPCGN_16725 (nanA) +0.1
N-acylmannosamine kinase:
N-acetyl-D-mannosamine + ATP→N-acetyl-D-mannosamine 6-phosphate + ADP + H+ (EC 2.7.1.60)
HEPCGN_16740 (nanK) -0.2
N-acylglucosamine-6-phosphate 2-epimerase:
N-acetyl-D-mannosamine 6-phosphate→N-acetyl-D-glucosamine 6-phosphate (EC 5.1.3.9)
HEPCGN_10900 +0.0
HEPCGN_16735 (nanE) +0.1
N-acetylglucosamine-6-phosphate deacetylase:
N-acetyl-D-glucosamine 6-phosphate + H2O→D-glucosamine 6-phosphate + acetate (EC 3.5.1.25)
HEPCGN_01065 (nagA) -0.2
HEPCGN_17145 (nagA) +0.3
Glucosamine-6-phosphate deaminase:
D-glucosamine 6-phosphate + H2O→β-D-fructofuranose 6-phosphate + ammonium (EC 3.5.99.6)
HEPCGN_01070 (nagB) +0.1
6-phosphofructokinase:
β-D-fructofuranose 6-phosphate + ATP→β-D-fructofuranose 1,6-bisphosphate + ADP + H+ (EC 2.7.1.11)
HEPCGN_05400 (pfkB) +0.0
HEPCGN_12475 (pfkA) +0.4
Fructose-bisphosphate aldolase:
β-D-fructofuranose 1,6-bisphosphate→glycerone phosphate + D-glyceraldehyde 3-phosphate (EC 4.1.2.13)
HEPCGN_02790 (fbaB) -0.1
HEPCGN_14330 -0.1
HEPCGN_14335 (fba) -0.1
HEPCGN_15410 (fba) -0.1
HEPCGN_18705 (fbaA) N.D.
Fructose-bisphosphatase:
β-D-fructofuranose 1,6-bisphosphate + H2O→β-D-fructofuranose 6-phosphate + phosphate (EC 3.1.3.11)
HEPCGN_01595 (ybhA) -0.0
HEPCGN_07265 (phoA) +0.1
HEPCGN_10145 (fbp) -4.2
HEPCGN_12425 (glpX) +0.1
HEPCGN_18655 (glpX) -0.0
Triose-phosphate isomerase (in reverse):
glycerone phosphate→D-glyceraldehyde 3-phosphate (EC 5.3.1.1)
HEPCGN_12455 (tpiA) N.D.
Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating):
D-glyceraldehyde 3-phosphate + NAD+ + phosphate→3-phospho-D-glyceroyl phosphate + NADH + H+ (EC 1.2.1.12)
HEPCGN_05120 (gapA) N.D.
HEPCGN_26125 (gap) -0.0
Phosphoglycerate kinase (in reverse):
3-phospho-D-glyceroyl phosphate + ADP→3-phospho-D-glycerate + ATP (EC 2.7.2.3)
HEPCGN_18700 (pgk) N.D.
3-phospho-D-glycerate→2-phospho-D-glycerate (EC 5.4.2.12)
HEPCGN_01540 (gpmA) -0.6
HEPCGN_09160 -0.2
HEPCGN_14575 (gpmM) -0.1
3-phospho-D-glycerate→2-phospho-D-glycerate (EC 5.4.2.11)
HEPCGN_01540 (gpmA) -0.6
Phosphopyruvate hydratase:
2-phospho-D-glycerate→phosphoenolpyruvate + H2O (EC 4.2.1.11)
HEPCGN_19525 (eno) N.D.
Pyruvate, water dikinase:
pyruvate + ATP + H2O→phosphoenolpyruvate + AMP + 2 H+ + phosphate (EC 2.7.9.2)
HEPCGN_05510 (ppsA) -8.0
Pyruvate kinase (in reverse):
phosphoenolpyruvate + ADP + H+→pyruvate + ATP (EC 2.7.1.40)
HEPCGN_04725 (pyk) +0.6
HEPCGN_05675 (pykF) -0.6
Formate C-acetyltransferase (in reverse):
pyruvate + coenzyme A→acetyl-CoA + formate (EC 2.3.1.54)
HEPCGN_01895 (ybiW) -0.0
HEPCGN_01900 (ybiY) +0.2
HEPCGN_12260 (pflC) +0.5
HEPCGN_12265 (pflD) +0.0
HEPCGN_14175 (cutD) +0.0
HEPCGN_14180 (cutC) -0.1
HEPCGN_17250 (tdcE) -0.1
HEPCGN_20470 (grcA) -0.0
HEPCGN_23005 (pflA) +0.1
HEPCGN_23010 (pflB) +0.1
Acetaldehyde dehydrogenase (acetylating) (in reverse):
acetyl-CoA + NADH + H+→acetaldehyde + coenzyme A + NAD+ (EC 1.2.1.10)
HEPCGN_07390 (mhpF) +0.1
HEPCGN_14195 (adhE) +0.0
HEPCGN_21215 (eutE) -0.0
HEPCGN_25070 (adhE) -0.1
Phosphate acetyltransferase:
acetyl-CoA + phosphate→acetyl phosphate + coenzyme A (EC 2.3.1.8)
HEPCGN_14165 +0.3
HEPCGN_21200 (pta) -0.5
HEPCGN_21995 (pta) +0.2
Acetate kinase (in reverse):
acetyl phosphate + ADP→acetate + ATP (EC 2.7.2.1; 2.7.2.15)
HEPCGN_04755 (purT) -0.1
HEPCGN_17245 (tdcD) -0.2
HEPCGN_21185 (eutP) N.D.
HEPCGN_21190 (eutQ) +0.2
HEPCGN_22000 (ackA) -0.2
Alcohol dehydrogenase (in reverse):
acetaldehyde + NADH + H+→ethanol + NAD+ (EC 1.1.1.1)
HEPCGN_07365 (frmA) +0.3
HEPCGN_07515 (yahK) -0.0
HEPCGN_09935 (ahr) +0.1
HEPCGN_14690 (yiaY) -0.1
HEPCGN_16580 (acuI) -0.2
HEPCGN_25070 (adhE) -0.1
HEPCGN_26430 (adhP) +0.1

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information