MetaCyc Pathway: L-homoserine biosynthesis in Escherichia coli ECOR27

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Reactions and Genes L-Rhamnose
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Aspartate kinase:
L-aspartate + ATP→L-aspartyl-4-phosphate + ADP (EC 2.7.2.4)
NOLOHH_03440 (thrA) -3.9
NOLOHH_05340 (lysC) -0.4
NOLOHH_05815 (metL) +0.5
Aspartate-semialdehyde dehydrogenase (in reverse):
L-aspartyl-4-phosphate + NADPH + H+→L-aspartate 4-semialdehyde + NADP+ + phosphate (EC 1.2.1.11)
NOLOHH_08665 (asd) N.D.
NOLOHH_14300 (usg) +0.6
Homoserine dehydrogenase (in reverse):
L-aspartate 4-semialdehyde + NAD(P)H + H+→L-homoserine + NAD(P)+ (EC 1.1.1.3)
NOLOHH_03440 (thrA) -3.9
NOLOHH_05815 (metL) +0.5

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information