MetaCyc Pathway: superpathway of anaerobic sucrose degradation in Escherichia coli ECOR38

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Reactions and Genes Sodium-DL-Lactate
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Sucrose synthase (in reverse):
sucrose + H+ + UDP→β-D-fructofuranose + UDP-α-D-glucose (EC 2.4.1.13)
No genes
Fructokinase:
β-D-fructofuranose + ATP→β-D-fructofuranose 6-phosphate + ADP + H+ (EC 2.7.1.4)
HEPCGN_07205 (mak) -0.4
HEPCGN_12655 (yihV) -0.0
HEPCGN_14340 +0.2
HEPCGN_16555 -0.2
HEPCGN_19180 -0.3
UTP-monosaccharide-1-phosphate uridylyltransferase (in reverse):
UDP-α-D-glucose + diphosphate→α-D-glucopyranose 1-phosphate + H+ + UTP (EC 2.7.7.64; 2.7.7.9)
HEPCGN_03100 (galF) -0.3
HEPCGN_25050 (galU) +0.2
6-phosphofructokinase:
β-D-fructofuranose 6-phosphate + ATP→β-D-fructofuranose 1,6-bisphosphate + ADP + H+ (EC 2.7.1.11)
HEPCGN_05400 (pfkB) +0.3
HEPCGN_12475 (pfkA) -0.1
Phosphoglucomutase:
α-D-glucopyranose 1-phosphate→D-glucopyranose 6-phosphate (EC 5.4.2.2)
HEPCGN_01125 (pgm) +0.0
HEPCGN_16945 (glmM) N.D.
Fructose-bisphosphate aldolase:
β-D-fructofuranose 1,6-bisphosphate→glycerone phosphate + D-glyceraldehyde 3-phosphate (EC 4.1.2.13)
HEPCGN_02790 (fbaB) -0.1
HEPCGN_14330 -0.1
HEPCGN_14335 (fba) -0.3
HEPCGN_15410 (fba) +0.2
HEPCGN_18705 (fbaA) N.D.
Fructose-bisphosphatase:
β-D-fructofuranose 1,6-bisphosphate + H2O→β-D-fructofuranose 6-phosphate + phosphate (EC 3.1.3.11)
HEPCGN_01595 (ybhA) +0.3
HEPCGN_07265 (phoA) +0.3
HEPCGN_10145 (fbp) -4.9
HEPCGN_12425 (glpX) +0.1
HEPCGN_18655 (glpX) -0.0
Glucose-6-phosphate isomerase:
α-D-glucose 6-phosphate→β-D-fructofuranose 6-phosphate (EC 5.3.1.9)
HEPCGN_11685 (pgi) -0.6
HEPCGN_19590 (kduI) -0.2
Triose-phosphate isomerase (in reverse):
glycerone phosphate→D-glyceraldehyde 3-phosphate (EC 5.3.1.1)
HEPCGN_12455 (tpiA) N.D.
Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating):
D-glyceraldehyde 3-phosphate + NAD+ + phosphate→3-phospho-D-glyceroyl phosphate + NADH + H+ (EC 1.2.1.12)
HEPCGN_05120 (gapA) N.D.
HEPCGN_26125 (gap) +0.2
Phosphoglycerate kinase (in reverse):
3-phospho-D-glyceroyl phosphate + ADP→3-phospho-D-glycerate + ATP (EC 2.7.2.3)
HEPCGN_18700 (pgk) N.D.
3-phospho-D-glycerate→2-phospho-D-glycerate (EC 5.4.2.12)
HEPCGN_01540 (gpmA) -1.4
HEPCGN_09160 -0.3
HEPCGN_14575 (gpmM) -0.1
3-phospho-D-glycerate→2-phospho-D-glycerate (EC 5.4.2.11)
HEPCGN_01540 (gpmA) -1.4
Phosphopyruvate hydratase:
2-phospho-D-glycerate→phosphoenolpyruvate + H2O (EC 4.2.1.11)
HEPCGN_19525 (eno) N.D.
Pyruvate kinase (in reverse):
phosphoenolpyruvate + ADP + H+→pyruvate + ATP (EC 2.7.1.40)
HEPCGN_04725 (pyk) +0.6
HEPCGN_05675 (pykF) +0.9
L-lactate dehydrogenase (in reverse):
pyruvate + NADH + H+→(S)-lactate + NAD+ (EC 1.1.1.27)
HEPCGN_07625 (ykgF) +0.1
HEPCGN_07630 (ykgE) +0.3
HEPCGN_10705 -0.0
HEPCGN_10710 -0.1
Pyruvate, water dikinase:
pyruvate + ATP + H2O→phosphoenolpyruvate + AMP + 2 H+ + phosphate (EC 2.7.9.2)
HEPCGN_05510 (ppsA) -5.1
Pyruvate decarboxylase:
pyruvate + H+→acetaldehyde + CO2 (EC 4.1.1.1)
No genes
Alcohol dehydrogenase (in reverse):
acetaldehyde + NADH + H+→ethanol + NAD+ (EC 1.1.1.1)
HEPCGN_07365 (frmA) +0.2
HEPCGN_07515 (yahK) +0.3
HEPCGN_09935 (ahr) +0.1
HEPCGN_14690 (yiaY) -0.0
HEPCGN_16580 (acuI) +0.4
HEPCGN_25070 (adhE) -0.3
HEPCGN_26430 (adhP) +0.0

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information