MetaCyc Pathway: L-lysine biosynthesis III in Escherichia coli ECOR27

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Reactions and Genes L-Arabinose
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Aspartate kinase:
L-aspartate + ATP→L-aspartyl-4-phosphate + ADP
(EC 2.7.2.4)
NOLOHH_03440 (thrA) -2.0
NOLOHH_05340 (lysC) -0.5
NOLOHH_05815 (metL) -0.0
Aspartate-semialdehyde dehydrogenase (in reverse):
L-aspartyl-4-phosphate + NADPH + H+→L-aspartate 4-semialdehyde + NADP+ + phosphate
(EC 1.2.1.11)
NOLOHH_08665 (asd) N.D.
NOLOHH_14300 (usg) -2.3
L-aspartate 4-semialdehyde + pyruvate→(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H+ + H2O (EC 4.3.3.7)
NOLOHH_13575 (dapA) N.D.
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+→(S)-2,3,4,5-tetrahydrodipicolinate + NAD(P)+ + H2O (EC 1.17.1.8)
NOLOHH_03285 (dapB) N.D.
(S)-2,3,4,5-tetrahydrodipicolinate + H+ + H2O→L-α-amino-ε-keto-pimelate (spontaneous)
No genes
Diaminopimelate dehydrogenase (in reverse):
L-α-amino-ε-keto-pimelate + ammonium + NADPH + H+meso-diaminopimelate + NADP+ + H2O
(EC 1.4.1.16)
No genes
Diaminopimelate decarboxylase:
meso-diaminopimelate + H+→L-lysine + CO2
(EC 4.1.1.20)
NOLOHH_11830 (lysA) -2.8

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information