MetaCyc Pathway: mixed acid fermentation in Escherichia coli ECOR27

Reactions and Genes	L-Arabinose
Phosphoenolpyruvate carboxylase (in reverse): phosphoenolpyruvate + hydrogen carbonate→oxaloacetate + phosphate (EC 4.1.1.31)
NOLOHH_05740 (ppc)	-2.6
Pyruvate kinase (in reverse): phosphoenolpyruvate + ADP + H+→pyruvate + ATP (EC 2.7.1.40)
NOLOHH_16835 (pyk)	-1.9
NOLOHH_17810 (pykF)	+0.7
D-lactate dehydrogenase (in reverse): pyruvate + NADH + H+→(R)-lactate + NAD+ (EC 1.1.1.28)
NOLOHH_15190 (dld)	-0.3
NOLOHH_19530 (ldhA)	+0.3
Malate dehydrogenase (in reverse): oxaloacetate + NADH + H+→(S)-malate + NAD+ (EC 1.1.1.37; 1.1.1.38)
NOLOHH_09595 (mdh)	-0.8
NOLOHH_19035 (maeA)	+0.0
NOLOHH_22620 (hcxB)	+0.3
Formate C-acetyltransferase (in reverse): pyruvate + coenzyme A→acetyl-CoA + formate (EC 2.3.1.54)
NOLOHH_05760 (pflC)	-0.4
NOLOHH_05765 (pflD)	-0.1
NOLOHH_10195 (tdcE)	-0.2
NOLOHH_13015 (grcA)	+0.4
NOLOHH_22070 (pflB)	-1.1
NOLOHH_22075 (pflA)	+0.6
NOLOHH_22485 (ybiY)	+0.9
NOLOHH_22490 (ybiW)	+0.4
Acetaldehyde dehydrogenase (acetylating) (in reverse): acetyl-CoA + NADH + H+→acetaldehyde + coenzyme A + NAD+ (EC 1.2.1.10)
NOLOHH_01680 (mhpF)	-0.3
NOLOHH_13725 (eutE)	+0.1
NOLOHH_20445 (adhE)	+0.1
Citrate (Si)-synthase: acetyl-CoA + oxaloacetate + H2O→citrate + coenzyme A + H+ (EC 2.3.3.1; 2.3.3.16; 2.3.3.3)
NOLOHH_23345 (gltA)	-1.9
formate + H+→CO2 + H2
NOLOHH_05025 (fdhF)	+0.0
NOLOHH_12420 (hycB)	+0.7
NOLOHH_12425 (hycC)	-0.1
NOLOHH_12430 (hycD)	+0.3
NOLOHH_13550 (hyfC)	-0.1
Fumarate hydratase: (S)-malate→fumarate + H2O (EC 4.2.1.2)
NOLOHH_04790 (fumB)	+0.0
NOLOHH_11260 (fumE)	-0.3
NOLOHH_17815 (fumD)	+0.1
NOLOHH_18150 (fumB)	+0.4
NOLOHH_18155 (fumC)	+0.4
Phosphate acetyltransferase: acetyl-CoA + phosphate→acetyl phosphate + coenzyme A (EC 2.3.1.8)
NOLOHH_13710 (pta)	+0.5
NOLOHH_14410 (pta)	N.D.
NOLOHH_15965	+0.1
Acetate kinase (in reverse): acetyl phosphate + ADP→acetate + ATP (EC 2.7.2.1; 2.7.2.15)
NOLOHH_10190 (tdcD)	-0.3
NOLOHH_13695 (eutP)	-0.4
NOLOHH_13700 (eutQ)	-1.4
NOLOHH_14415 (ackA)	N.D.
NOLOHH_16860 (purT)	+0.3
Aconitate hydratase: citrate→cis-aconitate + H2O (EC 4.2.1.3)
NOLOHH_02825 (acnB)	-0.1
NOLOHH_20240 (acnA)	-0.4
NOLOHH_23085 (ybhJ)	+0.3
Alcohol dehydrogenase (in reverse): acetaldehyde + NADH + H+→ethanol + NAD+ (EC 1.1.1.1)
NOLOHH_01650 (frmA)	-0.4
NOLOHH_01805 (yahK)	-0.3
NOLOHH_04010 (ahr)	-0.1
NOLOHH_07750 (yiaY)	-0.1
NOLOHH_09500 (acuI)	+0.1
NOLOHH_19040 (adhP)	-0.9
NOLOHH_20445 (adhE)	+0.1
Succinate dehydrogenase (ubiquinone): fumarate[in] + a menaquinol→succinate[in] + a menaquinone (EC 1.3.5.1)
NOLOHH_04605 (frdA)	+0.4
NOLOHH_04610 (frdB)	+0.0
NOLOHH_04615	+0.2
NOLOHH_04620 (frdD)	-0.3
Aconitate hydratase: cis-aconitate + H2O→D-threo-isocitrate (EC 4.2.1.3)
NOLOHH_02825 (acnB)	-0.1
NOLOHH_20240 (acnA)	-0.4
NOLOHH_23085 (ybhJ)	+0.3
Isocitrate dehydrogenase (NADP(+)): D-threo-isocitrate + NADP+→CO2 + 2-oxoglutarate + NADPH (EC 1.1.1.42)
NOLOHH_20885 (icd)	N.D.

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information