MetaCyc Pathway: superpathway of L-threonine biosynthesis in Escherichia coli ECOR27

Add experiment(s):


Reactions and Genes D-Glucose
remove
Aspartate transaminase (in reverse):
oxaloacetate + L-glutamate→L-aspartate + 2-oxoglutarate (EC 2.6.1.1)
NOLOHH_03790 (yjiR) -0.0
NOLOHH_21940 (aspC) -4.3
Aspartate kinase:
L-aspartate + ATP→L-aspartyl-4-phosphate + ADP (EC 2.7.2.4)
NOLOHH_03440 (thrA) -2.9
NOLOHH_05340 (lysC) -0.1
NOLOHH_05815 (metL) -0.2
Aspartate-semialdehyde dehydrogenase (in reverse):
L-aspartyl-4-phosphate + NADPH + H+→L-aspartate 4-semialdehyde + NADP+ + phosphate (EC 1.2.1.11)
NOLOHH_08665 (asd) N.D.
NOLOHH_14300 (usg) -0.6
Homoserine dehydrogenase (in reverse):
L-aspartate 4-semialdehyde + NAD(P)H + H+→L-homoserine + NAD(P)+ (EC 1.1.1.3)
NOLOHH_03440 (thrA) -2.9
NOLOHH_05815 (metL) -0.2
Homoserine kinase:
L-homoserine + ATP→O-phospho-L-homoserine + ADP + H+ (EC 2.7.1.39)
NOLOHH_03435 (thrB) -6.4
Threonine synthase:
O-phospho-L-homoserine + H2O→L-threonine + phosphate (EC 4.2.3.1)
NOLOHH_03430 (thrC) -6.1

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information