MetaCyc Pathway: L-lysine biosynthesis VI in Escherichia coli ECOR27

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Reactions and Genes D-Glucose
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Aspartate kinase:
L-aspartate + ATP→L-aspartyl-4-phosphate + ADP
(EC 2.7.2.4)
NOLOHH_03440 (thrA) -2.9
NOLOHH_05340 (lysC) -0.1
NOLOHH_05815 (metL) -0.2
Aspartate-semialdehyde dehydrogenase (in reverse):
L-aspartyl-4-phosphate + NADPH + H+→L-aspartate 4-semialdehyde + NADP+ + phosphate
(EC 1.2.1.11)
NOLOHH_08665 (asd) N.D.
NOLOHH_14300 (usg) -0.5
L-aspartate 4-semialdehyde + pyruvate→(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H+ + H2O (EC 4.3.3.7)
NOLOHH_13575 (dapA) N.D.
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+→(S)-2,3,4,5-tetrahydrodipicolinate + NAD(P)+ + H2O (EC 1.17.1.8)
NOLOHH_03285 (dapB) N.D.
LL-diaminopimelate aminotransferase (in reverse):
(S)-2,3,4,5-tetrahydrodipicolinate + L-glutamate + H+ + H2O→L,L-diaminopimelate + 2-oxoglutarate
(EC 2.6.1.83)
No genes
Diaminopimelate epimerase:
L,L-diaminopimelate→meso-diaminopimelate
(EC 5.1.1.7)
NOLOHH_06560 (dapF) N.D.
NOLOHH_16845 (zwf) -2.0
Diaminopimelate decarboxylase:
meso-diaminopimelate + H+→L-lysine + CO2
(EC 4.1.1.20)
NOLOHH_11830 (lysA) -3.9

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information