MetaCyc Pathway: TCA cycle VII (acetate-producers) in Hydrogenophaga sp. GW460-11-11-14-LB1

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Reactions and Genes Ying_all64 rep C; time point 3
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2-oxoglutarate synthase:
2-oxoglutarate + coenzyme A + 2 an oxidized ferredoxin [iron-sulfur] cluster→succinyl-CoA + CO2 + H+ + 2 a reduced ferredoxin [iron-sulfur] cluster (EC 1.2.7.3)
No genes
succinyl-CoA + acetate→acetyl-CoA + succinate (EC 2.8.3.18)
No genes
Succinate dehydrogenase (ubiquinone):
succinate[in] + an electron-transfer quinone→fumarate[in] + an electron-transfer quinol (EC 1.3.5.1)
GFF3367 N.D.
Fumarate hydratase (in reverse):
fumarate + H2O→(S)-malate (EC 4.2.1.2)
GFF4099 -0.4
GFF4101 +0.7
(S)-malate[in] + an electron-transfer quinone→oxaloacetate[in] + an electron-transfer quinol (EC 1.1.5.4)
No genes
Citrate (Si)-synthase:
acetyl-CoA + oxaloacetate + H2O→citrate + coenzyme A + H+ (EC 2.3.3.1; 2.3.3.16; 2.3.3.3)
GFF3099 +0.3
GFF3365 N.D.
GFF4314 +0.3
GFF890 +0.4
Aconitate hydratase:
citrate→cis-aconitate + H2O (EC 4.2.1.3)
GFF3374 -1.1
GFF3382 -1.0
Aconitate hydratase:
cis-aconitate + H2O→D-threo-isocitrate (EC 4.2.1.3)
GFF3374 -1.1
GFF3382 -1.0
Isocitrate dehydrogenase (NADP(+)):
D-threo-isocitrate + NADP+→2-oxoglutarate + CO2 + NADPH (EC 1.1.1.42)
GFF4513 +0.8
GFF4515 +0.0

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information