MetaCyc Pathway: 4-hydroxy-2-nonenal detoxification in Hydrogenophaga sp. GW460-11-11-14-LB1

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Reactions and Genes Ying_all64 rep C; time point 3
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Glutathione transferase:
4-hydroxy-2-nonenal + glutathione→(glutathion-S-yl)-4-hydroxy-2-nonenal (EC 2.5.1.18)
GFF1619 -0.2
GFF1718 -0.1
GFF1753 -1.1
GFF1814 -0.1
GFF2048 -0.1
GFF2496 -0.2
GFF2520 +0.1
GFF2759 -0.2
GFF2760 +0.1
GFF3086 -0.0
GFF3760 +0.3
GFF431 N.D.
GFF4492 -0.1
GFF4604 -0.3
GFF4799 N.D.
GFF5113 -1.3
GFF5241 +0.5
GFF658 -0.2
GFF863 +0.1
(glutathion-S-yl)-4-hydroxy-2-nonenal + H2O→S-(4-hydroxy-nonenal-3-yl)-L-cysteinylglycine + L-glutamate (EC 3.4.19.13)
No genes
S-(4-hydroxy-nonenal-3-yl)-L-cysteinylglycine + H2O→S-(4-hydroxy-nonenal-3-yl)-L-cysteine + glycine (EC 3.4.13.23)
No genes
Cysteine-S-conjugate N-acetyltransferase:
S-(4-hydroxy-nonenal-3-yl)-L-cysteine + acetyl-CoA→4-hydroxy-2-nonenal-N-acetyl-L-cysteine + coenzyme A + H+ (EC 2.3.1.80)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information