MetaCyc Pathway: superpathway of anaerobic energy metabolism (invertebrates) in Serratia liquefaciens MT49

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Reactions and Genes Survival; Treatment=FW300; TreatmentDuration=8weeks; Outgrowth=LB_kan30
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Phosphoenolpyruvate carboxykinase (GTP) (in reverse):
phosphoenolpyruvate + CO2 + GDP→oxaloacetate + GTP (EC 4.1.1.32)
No genes
Pyruvate kinase (in reverse):
phosphoenolpyruvate + ADP + H+→pyruvate + ATP (EC 2.7.1.40)
IAI46_11185 -1.3
IAI46_14585 -4.6
Phosphoenolpyruvate carboxykinase (GTP) (in reverse):
phosphoenolpyruvate + CO2 + IDP→oxaloacetate + ITP (EC 4.1.1.32)
No genes
Alanine transaminase (in reverse):
pyruvate + L-glutamate→2-oxoglutarate + L-alanine (EC 2.6.1.2)
IAI46_17720 +0.2
IAI46_18180 -0.4
Malate dehydrogenase (in reverse):
oxaloacetate + NADH + H+→(S)-malate + NAD+ (EC 1.1.1.37; 1.1.1.38)
IAI46_01825 -6.1
IAI46_07935 +0.4
IAI46_10380 -0.4
Malate dehydrogenase (oxaloacetate-decarboxylating):
(S)-malate + NAD+→pyruvate + CO2 + NADH (EC 1.1.1.38)
IAI46_07935 +0.4
Alanine racemase:
L-alanine→D-alanine (EC 5.1.1.1; 5.1.1.10)
IAI46_11595 +0.2
IAI46_14455 -2.0
IAI46_21725 -0.0
IAI46_22945 +0.3
IAI46_23640 +0.0
Aspartate transaminase:
2-oxoglutarate + L-aspartate→L-glutamate + oxaloacetate (EC 2.6.1.1)
IAI46_00175 -0.2
IAI46_06940 -0.2
IAI46_07315 -0.3
IAI46_08750 +0.3
IAI46_10415 +0.7
IAI46_14690 -0.3
IAI46_15405 -0.2
IAI46_16415 -0.2
IAI46_17720 +0.2
IAI46_17905 +0.1
IAI46_17940 +0.2
IAI46_19310 -0.6
IAI46_19885 -0.4
Fumarate hydratase:
(S)-malate→fumarate + H2O (EC 4.2.1.2)
IAI46_11655 -4.3
IAI46_21370 +0.4
pyruvate + coenzyme A + NAD+→CO2 + acetyl-CoA + NADH (EC 1.2.1.104)
IAI46_21315 N.D.
IAI46_21320 N.D.
IAI46_21325 -4.2
Succinate dehydrogenase (ubiquinone) (in reverse):
fumarate[in] + a rhodoquinol→succinate[in] + a rhodoquinone (EC 1.3.5.1)
No genes
acetyl-CoA + succinate→acetate + succinyl-CoA (EC 2.8.3.18)
No genes
succinate + propanoyl-CoA→succinyl-CoA + propanoate (EC 2.8.3.27)
No genes
Methylmalonyl-CoA mutase (in reverse):
succinyl-CoA→(R)-methylmalonyl-CoA (EC 5.4.99.2)
No genes
Succinate--CoA ligase (ADP-forming) (in reverse):
succinyl-CoA + ADP + phosphate→succinate + ATP + coenzyme A (EC 6.2.1.5)
IAI46_06285 -1.4
IAI46_06290 -3.0
Methylmalonyl-CoA epimerase:
(R)-methylmalonyl-CoA→(S)-methylmalonyl-CoA (EC 5.1.99.1)
No genes
Propionyl-CoA carboxylase (in reverse):
(S)-methylmalonyl-CoA + ADP + H+ + phosphate→propanoyl-CoA + ATP + hydrogen carbonate (EC 6.4.1.3)
IAI46_17830 N.D.
IAI46_20180 N.D.

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information