MetaCyc Pathway: superpathway of coenzyme A biosynthesis I (bacteria) in Escherichia coli ECRC101

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Reactions and Genes Casamino-acids
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3-methyl-2-oxobutanoate hydroxymethyltransferase:
3-methyl-2-oxobutanoate + a 5,10-methylenetetrahydrofolate + H2O→2-dehydropantoate + a tetrahydrofolate (EC 2.1.2.11)
MCAODC_00915 (panB) -1.8
Aspartate 1-decarboxylase:
L-aspartate + H+→β-alanine + CO2 (EC 4.1.1.11)
MCAODC_00930 (panD) -1.2
2-dehydropantoate 2-reductase (in reverse):
2-dehydropantoate + NADPH + H+→(R)-pantoate + NADP+ (EC 1.1.1.169)
MCAODC_05130 (ilvC) +0.1
MCAODC_27620 (panE) -0.6
Pantoate--beta-alanine ligase:
β-alanine + (R)-pantoate + ATP→(R)-pantothenate + AMP + diphosphate + H+ (EC 6.3.2.1)
MCAODC_00920 (panC) -1.3
Pantothenate kinase:
(R)-pantothenate + ATP→(R)-4'-phosphopantothenate + ADP + H+ (EC 2.7.1.33)
MCAODC_03985 (coaA) N.D.
Phosphopantothenate--cysteine ligase:
(R)-4'-phosphopantothenate + CTP + L-cysteine→(R)-4'-phosphopantothenoyl-L-cysteine + CMP + diphosphate + H+ (EC 6.3.2.5)
MCAODC_06125 (coaBC) N.D.
Phosphopantothenoylcysteine decarboxylase:
(R)-4'-phosphopantothenoyl-L-cysteine + H+→4'-phosphopantetheine + CO2 (EC 4.1.1.36)
MCAODC_06125 (coaBC) N.D.
Pantetheine-phosphate adenylyltransferase:
4'-phosphopantetheine + ATP + H+→3'-dephospho-CoA + diphosphate (EC 2.7.7.3)
MCAODC_06150 (coaD) N.D.
Dephospho-CoA kinase:
3'-dephospho-CoA + ATP→coenzyme A + ADP + H+ (EC 2.7.1.24)
MCAODC_01075 (coaE) N.D.

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information