MetaCyc Pathway: superpathway of anaerobic sucrose degradation in Escherichia coli ECRC101

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Reactions and Genes Sodium-DL-Lactate
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Sucrose synthase (in reverse):
sucrose + H+ + UDP→β-D-fructofuranose + UDP-α-D-glucose (EC 2.4.1.13)
No genes
Fructokinase:
β-D-fructofuranose + ATP→β-D-fructofuranose 6-phosphate + ADP + H+ (EC 2.7.1.4)
MCAODC_04520 (yihV) -0.0
MCAODC_13000 (cscK) -0.1
MCAODC_27790 (mak) +0.1
UTP-monosaccharide-1-phosphate uridylyltransferase (in reverse):
UDP-α-D-glucose + diphosphate→α-D-glucopyranose 1-phosphate + H+ + UTP (EC 2.7.7.64; 2.7.7.9)
MCAODC_20535 (galF) -0.2
MCAODC_21670 (galU) +1.3
6-phosphofructokinase:
β-D-fructofuranose 6-phosphate + ATP→β-D-fructofuranose 1,6-bisphosphate + ADP + H+ (EC 2.7.1.11)
MCAODC_04330 (pfkA) -1.6
MCAODC_18375 (pfkB) -0.3
Phosphoglucomutase:
α-D-glucopyranose 1-phosphate→D-glucopyranose 6-phosphate (EC 5.4.2.2)
MCAODC_08590 (glmM) N.D.
MCAODC_26315 (pgm) +0.0
Fructose-bisphosphate aldolase:
β-D-fructofuranose 1,6-bisphosphate→glycerone phosphate + D-glyceraldehyde 3-phosphate (EC 4.1.2.13)
MCAODC_03240 (fba) +0.1
MCAODC_07010 (fba) +0.0
MCAODC_09915 (fbaA) N.D.
MCAODC_21055 (fbaB) -0.1
Fructose-bisphosphatase:
β-D-fructofuranose 1,6-bisphosphate + H2O→β-D-fructofuranose 6-phosphate + phosphate (EC 3.1.3.11)
MCAODC_02450 (fbp) -4.5
MCAODC_04280 (glpX) +0.1
MCAODC_09865 (glpX) -0.2
MCAODC_25900 (ybhA) -0.2
MCAODC_27850 (phoA) -0.2
Glucose-6-phosphate isomerase:
α-D-glucose 6-phosphate→β-D-fructofuranose 6-phosphate (EC 5.3.1.9)
MCAODC_03675 (pgi) -0.6
MCAODC_10445 (kduI) +0.2
Triose-phosphate isomerase (in reverse):
glycerone phosphate→D-glyceraldehyde 3-phosphate (EC 5.3.1.1)
MCAODC_04310 (tpiA) N.D.
Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating):
D-glyceraldehyde 3-phosphate + NAD+ + phosphate→3-phospho-D-glyceroyl phosphate + NADH + H+ (EC 1.2.1.12)
MCAODC_16240 (gap) +0.1
MCAODC_18680 (gapA) N.D.
Phosphoglycerate kinase (in reverse):
3-phospho-D-glyceroyl phosphate + ADP→3-phospho-D-glycerate + ATP (EC 2.7.2.3)
MCAODC_09910 (pgk) N.D.
3-phospho-D-glycerate→2-phospho-D-glycerate (EC 5.4.2.12)
MCAODC_01670 -0.3
MCAODC_06245 (gpmM) -0.0
MCAODC_25955 (gpmA) -0.8
3-phospho-D-glycerate→2-phospho-D-glycerate (EC 5.4.2.11)
MCAODC_25955 (gpmA) -0.8
Phosphopyruvate hydratase:
2-phospho-D-glycerate→phosphoenolpyruvate + H2O (EC 4.2.1.11)
MCAODC_10800 (eno) N.D.
Pyruvate kinase (in reverse):
phosphoenolpyruvate + ADP + H+→pyruvate + ATP (EC 2.7.1.40)
MCAODC_18120 (pykF) N.D.
MCAODC_19085 (pyk) -0.4
L-lactate dehydrogenase (in reverse):
pyruvate + NADH + H+→(S)-lactate + NAD+ (EC 1.1.1.27)
MCAODC_28325 (ykgF) -0.1
MCAODC_28330 (ykgE) +0.1
Pyruvate, water dikinase:
pyruvate + ATP + H2O→phosphoenolpyruvate + AMP + 2 H+ + phosphate (EC 2.7.9.2)
MCAODC_18265 (ppsA) -5.1
Pyruvate decarboxylase:
pyruvate + H+→acetaldehyde + CO2 (EC 4.1.1.1)
No genes
Alcohol dehydrogenase (in reverse):
acetaldehyde + NADH + H+→ethanol + NAD+ (EC 1.1.1.1)
MCAODC_02275 (ahr) +0.1
MCAODC_06370 (yiaY) +0.1
MCAODC_08235 (acuI) -0.2
MCAODC_16575 (adhP) -0.1
MCAODC_21655 (adhE) +0.1
MCAODC_27970 (frmA) -0.3
MCAODC_28155 (yahK) -0.1

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information