| Reactions and Genes | D-Glucose |
|---|
| remove |
Aspartate kinase:
L-aspartate + ATP→L-aspartyl-4-phosphate + ADP (EC 2.7.2.4) |
| MCAODC_01625 (thrA) | -3.1 |
| MCAODC_03680 (lysC) | +0.1 |
| MCAODC_04170 (metL) | -1.6 |
Aspartate-semialdehyde dehydrogenase (in reverse):
L-aspartyl-4-phosphate + NADPH + H+→L-aspartate 4-semialdehyde + NADP+ + phosphate (EC 1.2.1.11) |
| MCAODC_07405 (asd) | N.D. |
| MCAODC_13705 (usg) | +0.6 |
| L-aspartate 4-semialdehyde + pyruvate→(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H+ + H2O (EC 4.3.3.7) |
| MCAODC_12445 (dapA) | N.D. |
Homoserine dehydrogenase (in reverse):
L-aspartate 4-semialdehyde + NAD(P)H + H+→L-homoserine + NAD(P)+ (EC 1.1.1.3) |
| MCAODC_01625 (thrA) | -3.1 |
| MCAODC_04170 (metL) | -1.6 |
Homoserine kinase:
L-homoserine + ATP→O-phospho-L-homoserine + ADP + H+ (EC 2.7.1.39) |
| MCAODC_01620 (thrB) | -4.0 |
| (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+→(S)-2,3,4,5-tetrahydrodipicolinate + NAD(P)+ + H2O (EC 1.17.1.8) |
| MCAODC_01470 (dapB) | N.D. |
Cystathionine gamma-synthase:
O-phospho-L-homoserine + L-cysteine→L-cystathionine + phosphate (EC 2.5.1.48) |
| MCAODC_04175 (metB) | -3.8 |
LL-diaminopimelate aminotransferase (in reverse):
(S)-2,3,4,5-tetrahydrodipicolinate + L-glutamate + H+ + H2O→L,L-diaminopimelate + 2-oxoglutarate (EC 2.6.1.83) |
| No genes |
Threonine synthase:
O-phospho-L-homoserine + H2O→L-threonine + phosphate (EC 4.2.3.1) |
| MCAODC_01615 (thrC) | -5.5 |
Diaminopimelate epimerase:
L,L-diaminopimelate→meso-diaminopimelate (EC 5.1.1.7) |
| MCAODC_04935 (dapF) | N.D. |
| MCAODC_19070 (zwf) | -0.6 |
Cysteine-S-conjugate beta-lyase:
L-cystathionine→2-aminoprop-2-enoate + L-homocysteine (EC 4.4.1.13) |
| No genes |
Diaminopimelate decarboxylase:
meso-diaminopimelate + H+→L-lysine + CO2 (EC 4.1.1.20) |
| MCAODC_10470 (lysA) | -5.2 |
5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase:
L-homocysteine + 5-methyltetrahydropteroyl tri-L-glutamate→L-methionine + tetrahydropteroyl tri-L-glutamate (EC 2.1.1.14) |
| MCAODC_04830 (metE) | -3.2 |
Tryptophanase:
2-aminoprop-2-enoate→2-iminopropanoate (spontaneous) (EC 4.1.99.1; 4.1.99.2; 4.3.1.13; 4.3.1.17; 4.3.1.18; 4.3.3.8; 4.4.1.1; 4.4.1.13; 4.4.1.15; 4.4.1.25; 4.4.1.28; 4.4.1.35; 4.5.1.2) |
| MCAODC_05475 (tnaA) | +0.1 |
| MCAODC_08940 (tdcG) | +0.0 |
| MCAODC_10700 (sdaB) | -0.1 |
| MCAODC_12980 (dsdA) | -0.0 |
| MCAODC_18860 (sdaA) | +0.1 |
| MCAODC_19595 (dcyD) | -0.5 |
| 2-iminopropanoate + H2O→pyruvate + ammonium (spontaneous) (EC 3.5.99.10; 4.1.99.1; 4.1.99.2; 4.3.1.13; 4.3.1.17; 4.3.1.18; 4.3.3.8; 4.4.1.1; 4.4.1.13; 4.4.1.15; 4.4.1.25; 4.4.1.28; 4.4.1.35; 4.5.1.2) |
| MCAODC_02380 (ridA) | -0.2 |
| MCAODC_05475 (tnaA) | +0.1 |
| MCAODC_08935 (tdcF) | -0.0 |
| MCAODC_08940 (tdcG) | +0.0 |
| MCAODC_10700 (sdaB) | -0.1 |
| MCAODC_12980 (dsdA) | -0.0 |
| MCAODC_18860 (sdaA) | +0.1 |
| MCAODC_19595 (dcyD) | -0.5 |
Links:
Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information