MetaCyc Pathway: D-fructuronate degradation in Escherichia coli BW25113

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Reactions and Genes D-Galacturonic Acid (C) MOPS
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Fructuronate reductase (in reverse):
D-fructuronate + NADH + H+→D-mannonate + NAD+ (EC 1.1.1.57)
b1542 (ydfI) +0.1
b2172 (yeiQ) -0.4
b4323 (uxuB) +0.0
Mannonate dehydratase:
D-mannonate→2-dehydro-3-deoxy-D-gluconate + H2O (EC 4.2.1.8)
b4322 (uxuA) +0.0
2-dehydro-3-deoxy-D-gluconate + ATP→2-dehydro-3-deoxy-D-gluconate 6-phosphate + ADP + H+ (EC 2.7.1.178; 2.7.1.45)
b3526 (kdgK) -3.9
2-dehydro-3-deoxy-phosphogluconate aldolase:
2-dehydro-3-deoxy-D-gluconate 6-phosphate→D-glyceraldehyde 3-phosphate + pyruvate (EC 4.1.2.14; 4.1.2.55)
b1850 (eda) -4.1

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information