MetaCyc Pathway: superpathway of L-threonine biosynthesis in Pseudomonas simiae WCS417

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Reactions and Genes Gly-Glu (C)
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Aspartate transaminase (in reverse):
oxaloacetate + L-glutamate→L-aspartate + 2-oxoglutarate (EC 2.6.1.1)
PS417_08560 -0.1
PS417_09070 +0.0
PS417_09120 +0.0
PS417_11840 -0.0
PS417_12775 +0.1
PS417_12985 -0.2
PS417_13545 +0.1
PS417_14865 +0.1
PS417_15040 -0.4
PS417_15990 -0.1
PS417_19025 -0.0
PS417_19385 -0.0
PS417_19910 +0.0
PS417_21030 -2.2
PS417_21275 -0.5
PS417_23120 -0.0
PS417_27730 +0.1
PS417_28165 -0.0
Aspartate kinase:
L-aspartate + ATP→L-aspartyl-4-phosphate + ADP (EC 2.7.2.4)
PS417_21655 -1.4
Aspartate-semialdehyde dehydrogenase (in reverse):
L-aspartyl-4-phosphate + NADPH + H+→L-aspartate 4-semialdehyde + NADP+ + phosphate (EC 1.2.1.11)
PS417_06650 N.D.
PS417_18575 +0.0
PS417_18580 N.D.
Homoserine dehydrogenase (in reverse):
L-aspartate 4-semialdehyde + NAD(P)H + H+→L-homoserine + NAD(P)+ (EC 1.1.1.3)
PS417_22885 N.D.
Homoserine kinase:
L-homoserine + ATP→O-phospho-L-homoserine + ADP + H+ (EC 2.7.1.39)
PS417_21120 +0.2
PS417_00395 N.D.
Threonine synthase:
O-phospho-L-homoserine + H2O→L-threonine + phosphate (EC 4.2.3.1)
PS417_22880 N.D.

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information