MetaCyc Pathway: adipate degradation in Pseudomonas fluorescens GW456-L13

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Reactions and Genes octanoate (C)
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Succinate--CoA ligase (ADP-forming):
adipate + ATP + coenzyme A→adipoyl-CoA + ADP + phosphate (EC 6.2.1.5)
PfGW456L13_4265 N.D.
PfGW456L13_4266 N.D.
adipoyl-CoA + an oxidized electron-transfer flavoprotein + H+→(2E)-5-carboxy-2-pentenoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.7)
PfGW456L13_1153 -2.4
PfGW456L13_1155 +1.0
PfGW456L13_1156 -3.2
PfGW456L13_1387 +0.2
PfGW456L13_224 +0.3
PfGW456L13_3166 +0.0
PfGW456L13_4891 -0.1
Enoyl-CoA hydratase (in reverse):
(2E)-5-carboxy-2-pentenoyl-CoA + H2O→(3S)-hydroxyadipyl-CoA (EC 4.2.1.17)
PfGW456L13_1812 +0.0
PfGW456L13_2246 -1.2
PfGW456L13_2412 -0.3
PfGW456L13_2433 -0.8
PfGW456L13_2434 +0.7
PfGW456L13_2533 -0.3
PfGW456L13_2535 +0.2
PfGW456L13_2984 -0.1
PfGW456L13_2986 +0.0
PfGW456L13_3210 -0.5
PfGW456L13_3244 -0.4
PfGW456L13_3388 -0.1
PfGW456L13_3427 -0.8
PfGW456L13_3636 +0.2
PfGW456L13_4041 -1.0
PfGW456L13_412 -0.1
PfGW456L13_4142 N.D.
PfGW456L13_4146 +0.3
PfGW456L13_4531 +0.4
3-hydroxyacyl-CoA dehydrogenase:
(3S)-hydroxyadipyl-CoA + NAD+→3-oxoadipoyl-CoA + NADH + H+ (EC 1.1.1.35)
PfGW456L13_1094 -0.3
PfGW456L13_3395 -1.0
PfGW456L13_4041 -1.0
PfGW456L13_412 -0.1
PfGW456L13_4146 +0.3
3-oxoadipyl-CoA thiolase (in reverse):
3-oxoadipoyl-CoA + coenzyme A→succinyl-CoA + acetyl-CoA (EC 2.3.1.174)
PfGW456L13_2430 -1.4
PfGW456L13_3394 +0.1
PfGW456L13_4590 -0.3

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information