MetaCyc Pathway: adipate biosynthesis in Pseudomonas simiae WCS417

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Reactions and Genes L-Valine (C)
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3-oxoadipyl-CoA thiolase:
acetyl-CoA + succinyl-CoA→3-oxoadipoyl-CoA + coenzyme A
(EC 2.3.1.174)
PS417_06710 +0.5
3-hydroxyacyl-CoA dehydrogenase (in reverse):
3-oxoadipoyl-CoA + NADH + H+→(3S)-hydroxyadipyl-CoA + NAD+
(EC 1.1.1.35)
PS417_07575 -0.9
PS417_21215 +0.3
PS417_26285 -0.4
Enoyl-CoA hydratase:
(3S)-hydroxyadipyl-CoA→(2E)-5-carboxy-2-pentenoyl-CoA + H2O
(EC 4.2.1.17)
PS417_07030 -0.3
PS417_07575 -0.9
PS417_08535 +0.1
PS417_10680 -0.6
PS417_11445 -0.0
PS417_12870 -0.0
PS417_13835 -3.4
PS417_13845 N.D.
PS417_21195 +0.4
PS417_21215 +0.3
PS417_22625 +0.4
(2E)-5-carboxy-2-pentenoyl-CoA + FADH2→adipoyl-CoA + FAD + H+
No genes
Succinate--CoA ligase (ADP-forming) (in reverse):
adipoyl-CoA + ADP + phosphate→adipate + ATP + coenzyme A
(EC 6.2.1.5)
PS417_08910 N.D.
PS417_08915 N.D.

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information