MetaCyc Pathway: superpathway of salicylate degradation in Pseudomonas fluorescens GW456-L13

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Reactions and Genes L-Phenylalanine (C)
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Salicylate 1-monooxygenase:
salicylate + NADH + dioxygen + 2 H+→catechol + CO2 + NAD+ + H2O (EC 1.14.13.1)
No genes
Catechol 1,2-dioxygenase:
catechol + dioxygen→cis,cis-muconate + 2 H+ (EC 1.13.11.1)
PfGW456L13_3822 -0.2
Muconate cycloisomerase (in reverse):
cis,cis-muconate + H+→(+)-muconolactone (EC 5.5.1.1)
PfGW456L13_3824 -0.6
Muconolactone Delta-isomerase:
(+)-muconolactone→(4,5-dihydro-5-oxofuran-2-yl)-acetate (EC 5.3.3.4)
PfGW456L13_3823 -0.3
3-oxoadipate enol-lactonase:
(4,5-dihydro-5-oxofuran-2-yl)-acetate + H2O→3-oxoadipate + H+ (EC 3.1.1.24)
PfGW456L13_2295 +0.0
PfGW456L13_4459 +0.2
PfGW456L13_4585 +0.1
3-oxoadipate CoA-transferase:
3-oxoadipate + succinyl-CoA→3-oxoadipoyl-CoA + succinate (EC 2.8.3.6)
PfGW456L13_2531 +0.1
PfGW456L13_2532 +0.2
PfGW456L13_4591 +1.2
PfGW456L13_4592 +1.2
3-oxoadipyl-CoA thiolase (in reverse):
3-oxoadipoyl-CoA + coenzyme A→acetyl-CoA + succinyl-CoA (EC 2.3.1.174)
PfGW456L13_2430 +0.0
PfGW456L13_3394 +0.2
PfGW456L13_4590 -0.6

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information