MetaCyc Pathway: dTDP-L-daunosamine biosynthesis in Escherichia coli BW25113

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Reactions and Genes 2-Furfuraldehyde 0.25 vol%
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Glucose-1-phosphate thymidylyltransferase:
α-D-glucopyranose 1-phosphate + H+ + dTTP→dTDP-α-D-glucose + diphosphate
(EC 2.7.7.24)
b0363 (yaiP) -0.1
b2039 (rfbA) +0.2
b3789 (rffH) +0.2
dTDP-glucose 4,6-dehydratase:
dTDP-α-D-glucose→dTDP-4-dehydro-6-deoxy-α-D-glucopyranose + H2O
(EC 4.2.1.46)
b2041 (rfbB) +0.2
b3788 (rffG) -0.2
dTDP-4-dehydrorhamnose 3,5-epimerase:
dTDP-4-dehydro-6-deoxy-α-D-glucopyranose→dTDP-4-dehydro-β-L-rhamnose
(EC 5.1.3.13)
b2038 (rfbC) -1.4
dTDP-4-dehydro-β-L-rhamnose→dTDP-3,4-didehydro-2,6-dideoxy-β-L-glucose + H2O
No genes
dTDP-3,4-didehydro-2,6-dideoxy-β-L-glucose + L-glutamate→dTDP-3-amino-4-dehydro-2,3,6-trideoxy-β-L-glucose + 2-oxoglutarate
No genes
dTDP-3-amino-4-dehydro-2,3,6-trideoxy-β-L-glucose + NADPH + H+→dTDP-L-daunosamine + NADP+
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information