MetaCyc Pathway: superpathway of heme b biosynthesis from uroporphyrinogen-III in Escherichia coli BW25113

Reactions and Genes	methylglyoxal 0.008 vol%
Uroporphyrinogen decarboxylase: uroporphyrinogen-III + 4 H+→coproporphyrinogen III + 4 CO2 (EC 4.1.1.37)
b3997 (hemE)	N.D.
coproporphyrinogen III + 2 S-adenosyl-L-methionine→protoporphyrinogen IX + 2 CO2 + 2 5'-deoxyadenosine + 2 L-methionine (EC 1.3.98.3)
b3867 (hemN)	-0.2
Coproporphyrinogen oxidase: coproporphyrinogen III + dioxygen + 2 H+→protoporphyrinogen IX + 2 CO2 + 2 H2O (EC 1.3.3.3)
b2436 (hemF)	-0.0
protoporphyrinogen IX[in] + 3 a ubiquinone→protoporphyrin IX[in] + 3 a ubiquinol (EC 1.3.5.3)
b3850 (hemG)	N.D.
protoporphyrinogen IX[in] + 3 a menaquinone→protoporphyrin IX[in] + 3 a menaquinol (EC 1.3.5.3)
b3850 (hemG)	N.D.
protoporphyrin IX + Fe2+→protoheme + 2 H+ (EC 4.98.1.1)
b0475 (hemH)	N.D.
b1019 (ycdB)	+0.0
b2431 (b2431)	-2.9

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information