MetaCyc Pathway: superpathway of L-tyrosine biosynthesis in Agrobacterium fabrum C58

Reactions and Genes	D-Saccharic potassium salt (C)
3-deoxy-7-phosphoheptulonate synthase: D-erythrose 4-phosphate + phosphoenolpyruvate + H2O→3-deoxy-D-arabino-heptulosonate 7-phosphate + phosphate (EC 2.5.1.54)
Atu1610	N.D.
3-dehydroquinate synthase: 3-deoxy-D-arabino-heptulosonate 7-phosphate→3-dehydroquinate + phosphate (EC 4.2.3.4)
Atu3625	N.D.
3-dehydroquinate dehydratase: 3-dehydroquinate→3-dehydroshikimate + H2O (EC 4.2.1.10)
Atu1332	N.D.
Atu1426	N.D.
Atu4531	+0.2
Shikimate dehydrogenase (in reverse): 3-dehydroshikimate + NADPH + H+→shikimate + NADP+ (EC 1.1.1.25)
Atu0003	N.D.
Atu4295	-0.2
Atu4532	-0.2
Shikimate kinase: shikimate + ATP→shikimate 3-phosphate + ADP + H+ (EC 2.7.1.71)
Atu3626	N.D.
3-phosphoshikimate 1-carboxyvinyltransferase: shikimate 3-phosphate + phosphoenolpyruvate→5-enolpyruvoyl-shikimate 3-phosphate + phosphate (EC 2.5.1.19)
Atu0642	N.D.
Chorismate synthase: 5-enolpyruvoyl-shikimate 3-phosphate→chorismate + phosphate (EC 4.2.3.5)
Atu0754	N.D.
Chorismate mutase: chorismate→prephenate (EC 5.4.99.5)
Atu2698	N.D.
Prephenate dehydrogenase: prephenate + NAD+→3-(4-hydroxyphenyl)pyruvate + CO2 + NADH (EC 1.3.1.12)
Atu3611	N.D.
Aspartate transaminase (in reverse): 3-(4-hydroxyphenyl)pyruvate + L-glutamate→L-tyrosine + 2-oxoglutarate (EC 2.6.1.1; 2.6.1.27; 2.6.1.5; 2.6.1.57)
Atu0235	+0.0
Atu0529	-0.0
Atu1011	-0.3
Atu1589	-2.5
Atu1848	-2.6
Atu2015	-1.8
Atu2196	N.D.
Atu3612	N.D.
Atu4266	+0.2
Atu4278	-0.3

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information