MetaCyc Pathway: superpathway of microbial D-galacturonate and D-glucuronate degradation in Agrobacterium fabrum C58

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Reactions and Genes D-Saccharic potassium salt (C)
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Beta-glucuronidase:
a β-D-glucuronide + H2O→D-glucopyranuronate + an alcohol
(EC 3.2.1.31)
No genes
Galactarate dehydratase:
galactarate→5-dehydro-4-deoxy-D-glucarate + H2O
(EC 4.2.1.42)
Atu2822 -0.1
Glucarate dehydratase:
D-glucarate→5-dehydro-4-deoxy-D-glucarate + H2O
(EC 4.2.1.40)
Atu3029 -0.0
Uronate dehydrogenase:
β-D-glucuronate + NAD+→D-glucaro-1,5-lactone + NADH + H+
(EC 1.1.1.203)
Atu3143 +0.0
Atu3972 -3.6
D-galactopyranuronate→aldehydo-D-galacturonate (spontaneous)
No genes
4-deoxy-L-threo-hex-4-enopyranuronate→5-dehydro-4-deoxy-D-glucuronate (EC 4.2.99.25)
Atu3145 -0.5
Uronate dehydrogenase:
β-D-galacturonate + NAD+→D-galactaro-1,5-lactone + NADH + H+
(EC 1.1.1.203)
Atu3143 +0.0
Atu3972 -3.6
4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase:
5-dehydro-4-deoxy-D-glucuronate→3-deoxy-D-glycero-2,5-hexodiulosonate
(EC 5.3.1.17)
Atu3142 -0.1
Glucuronate isomerase:
aldehydo-D-galacturonate→D-tagaturonate
(EC 5.3.1.12)
No genes
2-dehydro-3-deoxyglucarate aldolase:
5-dehydro-4-deoxy-D-glucarate→(2R)-tartronate semialdehyde + pyruvate
(EC 4.1.2.20)
No genes
aldehydo-D-galacturonate + NADPH + H+→L-galactonate + NADP+ (EC 1.1.1.365)
No genes
D-glucopyranuronate→aldehydo-D-glucuronate (spontaneous)
No genes
D-galactaro-1,5-lactone→D-galactaro-1,4-lactone (EC 5.4.1.4)
Atu3138 +0.0
D-glucaro-1,5-lactone→D-glucaro-1,4-lactone (spontaneous) (EC 5.4.1.4)
No genes
2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase (in reverse):
3-deoxy-D-glycero-2,5-hexodiulosonate + NADH + H+→2-dehydro-3-deoxy-D-gluconate + NAD+
(EC 1.1.1.127)
Atu3531 -0.3
Tagaturonate reductase (in reverse):
D-tagaturonate + NADH + H+→D-altronate + NAD+
(EC 1.1.1.58)
Atu2813 -0.1
Glucuronate isomerase:
aldehydo-D-glucuronate→D-fructuronate
(EC 5.3.1.12)
No genes
L-galactonate→2-dehydro-3-deoxy-L-galactonate + H2O (EC 4.2.1.146)
Atu2811 +0.0
D-galactaro-1,4-lactone→5-dehydro-4-deoxy-D-glucarate + H+ (EC 5.5.1.27)
Atu3139 -0.1
D-glucaro-1,4-lactone→5-dehydro-4-deoxy-D-glucarate + H+ (EC 5.5.1.27)
Atu3139 -0.1
2-hydroxy-3-oxopropionate reductase (in reverse):
(2R)-tartronate semialdehyde + NAD(P)H + H+→D-glycerate + NAD(P)+
(EC 1.1.1.60)
Atu2737 +0.3
Atu3159 -0.0
Atu4085 -0.1
Atu5173 -0.5
5-dehydro-4-deoxyglucarate dehydratase:
5-dehydro-4-deoxy-D-glucarate + H+→2,5-dioxopentanoate + CO2 + H2O
(EC 4.2.1.41)
Atu3140 +4.0
Altronate dehydratase:
D-altronate→2-dehydro-3-deoxy-D-gluconate + H2O
(EC 4.2.1.7)
No genes
D-glycerate + ATP→2-phospho-D-glycerate + ADP + H+ (EC 2.7.1.165)
No genes
Fructuronate reductase (in reverse):
D-fructuronate + NADH + H+→D-mannonate + NAD+
(EC 1.1.1.57)
Atu3530 +0.2
2-dehydro-3-deoxy-L-galactonate→L-glyceraldehyde + pyruvate (EC 4.1.2.54)
No genes
2,5-dioxovalerate dehydrogenase:
2,5-dioxopentanoate + NADP+ + H2O→2-oxoglutarate + NADPH + 2 H+
(EC 1.2.1.26)
Atu3259 -1.3
Atu3498 +0.0
Mannonate dehydratase:
D-mannonate→2-dehydro-3-deoxy-D-gluconate + H2O
(EC 4.2.1.8)
Atu3257 +0.1
Atu3529 +0.2
Atu4625 -0.1
L-glyceraldehyde + NADPH + H+→glycerol + NADP+ (EC 1.1.1.372)
No genes
2-dehydro-3-deoxy-D-gluconate + ATP→2-dehydro-3-deoxy-D-gluconate 6-phosphate + ADP + H+ (EC 2.7.1.178; 2.7.1.45)
Atu2296 +0.2
2-dehydro-3-deoxy-phosphogluconate aldolase:
2-dehydro-3-deoxy-D-gluconate 6-phosphate→D-glyceraldehyde 3-phosphate + pyruvate
(EC 4.1.2.14; 4.1.2.55)
Atu4494 N.D.

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information