MetaCyc Pathway: superpathway of purine nucleotide salvage in Escherichia coli BW25113

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Reactions and Genes Bacitracin 1 mg/ml
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Adenosine kinase:
adenosine + ATP→AMP + ADP + H+ (EC 2.7.1.20)
No genes
Purine-nucleoside phosphorylase:
adenosine + phosphate→adenine + α-D-ribose-1-phosphate (EC 2.4.2.1)
b0391 (yaiE) +0.0
b2407 (xapA) +0.3
b2593 (yfiH) +1.9
b4384 (deoD) +0.2
Adenylosuccinate synthase:
IMP + L-aspartate + GTP→adenylosuccinate + GDP + 2 H+ + phosphate (EC 6.3.4.4)
b4177 (purA) +0.1
IMP dehydrogenase:
IMP + NAD+ + H2O→XMP + NADH + H+ (EC 1.1.1.205)
b2508 (guaB) N.D.
Purine-nucleoside phosphorylase:
guanosine + phosphate→guanine + α-D-ribose-1-phosphate (EC 2.4.2.1; 2.4.2.15)
b0391 (yaiE) +0.0
b2407 (xapA) +0.3
b4384 (deoD) +0.2
Adenine phosphoribosyltransferase (in reverse):
adenine + 5-phospho-α-D-ribose 1-diphosphate→AMP + diphosphate (EC 2.4.2.7)
b0469 (apt) +0.9
Adenylosuccinate lyase:
adenylosuccinate→AMP + fumarate (EC 4.3.2.2)
b1131 (purB) N.D.
GMP synthase (glutamine-hydrolyzing):
XMP + ATP + L-glutamine + H2O→GMP + AMP + L-glutamate + diphosphate + 2 H+ (EC 6.3.5.2)
b2507 (guaA) N.D.
Hypoxanthine phosphoribosyltransferase (in reverse):
guanine + 5-phospho-α-D-ribose 1-diphosphate→GMP + diphosphate (EC 2.4.2.8)
b0125 (hpt) +0.6
b0238 (gpt) -0.1
b0469 (apt) +0.9
Adenylate kinase:
AMP + ATP→2 ADP (EC 2.7.4.3)
b0474 (adk) N.D.
Guanylate kinase:
GMP + ATP→GDP + ADP (EC 2.7.4.8)
b3648 (gmk) N.D.
b4094 (phnN) -0.1
Ribonucleoside-diphosphate reductase (in reverse):
ADP + a reduced thioredoxin→dADP + an oxidized thioredoxin + H2O (EC 1.17.4.1)
b2234 (nrdA) N.D.
b2235 (nrdB) N.D.
b2674 (nrdI) -0.2
b2675 (nrdE) +0.1
b2676 (nrdF) +0.1
Nucleoside-diphosphate kinase:
GDP + ATP→GTP + ADP (EC 2.7.4.6)
b0474 (adk) N.D.
b2518 (ndk) -0.2
Nucleoside-diphosphate kinase:
dADP + ATP→ADP + dATP (EC 2.7.4.6)
b2518 (ndk) -0.2

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information