MetaCyc Pathway: siroheme biosynthesis in Escherichia coli BW25113

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Reactions and Genes Benzalkonium Chloride 0.004 mg/ml
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Uroporphyrinogen-III C-methyltransferase:
uroporphyrinogen-III + S-adenosyl-L-methionine→precorrin-1 + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.107)
b3368 (cysG) -0.2
b3803 (hemX) -1.5
Uroporphyrinogen-III C-methyltransferase:
precorrin-1 + S-adenosyl-L-methionine→precorrin-2 + S-adenosyl-L-homocysteine (EC 2.1.1.107)
b3368 (cysG) -0.2
b3803 (hemX) -1.5
Precorrin-2 dehydrogenase:
precorrin-2 + NAD+→sirohydrochlorin + NADH + 2 H+ (EC 1.3.1.76)
b3368 (cysG) -0.2
Sirohydrochlorin ferrochelatase:
sirohydrochlorin + Fe2+→siroheme + 2 H+ (EC 4.99.1.4)
b3368 (cysG) -0.2

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information