MetaCyc Pathway: glycerol degradation to butanol in Variovorax sp. OAS795

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Reactions and Genes butyrate (C)
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Glycerol dehydrogenase:
glycerol + NAD+→dihydroxyacetone + NADH + H+ (EC 1.1.1.6)
ABID97_RS11225 N.D.
Glycerone kinase:
dihydroxyacetone + ATP→glycerone phosphate + ADP + H+ (EC 2.7.1.29)
No genes
Triose-phosphate isomerase (in reverse):
glycerone phosphate→D-glyceraldehyde 3-phosphate (EC 5.3.1.1)
ABID97_RS20510 N.D.
Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating):
D-glyceraldehyde 3-phosphate + NAD+ + phosphate→3-phospho-D-glyceroyl phosphate + NADH + H+ (EC 1.2.1.12)
ABID97_RS02440 N.D.
Phosphoglycerate kinase (in reverse):
3-phospho-D-glyceroyl phosphate + ADP→3-phospho-D-glycerate + ATP (EC 2.7.2.3)
ABID97_RS01760 N.D.
ABID97_RS12890 N.D.
3-phospho-D-glycerate→2-phospho-D-glycerate (EC 5.4.2.12)
ABID97_RS06495 +2.6
ABID97_RS07385 N.D.
ABID97_RS23825 N.D.
Phosphopyruvate hydratase:
2-phospho-D-glycerate→phosphoenolpyruvate + H2O (EC 4.2.1.11)
ABID97_RS20195 N.D.
ABID97_RS28005 -2.2
ABID97_RS28010 N.D.
Pyruvate kinase (in reverse):
phosphoenolpyruvate + ADP + H+→pyruvate + ATP (EC 2.7.1.40)
ABID97_RS01755 -0.8
ABID97_RS24455 -0.4
ABID97_RS27675 +0.0
Pyruvate synthase:
pyruvate + coenzyme A + 2 an oxidized ferredoxin [iron-sulfur] cluster→acetyl-CoA + CO2 + H+ + 2 a reduced ferredoxin [iron-sulfur] cluster (EC 1.2.7.1)
No genes
Acetyl-CoA C-acyltransferase:
2 acetyl-CoA→acetoacetyl-CoA + coenzyme A (EC 2.3.1.16; 2.3.1.9)
ABID97_RS04675 -0.0
ABID97_RS05875 N.D.
ABID97_RS06005 +0.1
ABID97_RS10975 +0.2
ABID97_RS11335 +0.2
ABID97_RS11380 -0.0
ABID97_RS12420 N.D.
ABID97_RS15750 -0.1
ABID97_RS18615 -0.2
ABID97_RS18775 +0.2
ABID97_RS20240 -0.0
ABID97_RS24190 -0.4
ABID97_RS25195 -0.3
ABID97_RS26575 N.D.
ABID97_RS27835 -0.4
ABID97_RS28230 -0.7
ABID97_RS28270 -0.5
ABID97_RS28430 +0.1
3-hydroxyacyl-CoA dehydrogenase (in reverse):
acetoacetyl-CoA + NADH + H+→(S)-3-hydroxybutanoyl-CoA + NAD+ (EC 1.1.1.35)
ABID97_RS00810 N.D.
ABID97_RS03030 -0.1
ABID97_RS05865 +0.2
ABID97_RS06010 +0.2
ABID97_RS08805 -0.0
ABID97_RS10560 -0.4
ABID97_RS15740 +0.1
ABID97_RS17005 -0.1
ABID97_RS18595 N.D.
(S)-3-hydroxybutanoyl-CoA→crotonyl-CoA + H2O (EC 4.2.1.150)
ABID97_RS00815 -0.0
ABID97_RS01435 +0.1
ABID97_RS02880 +0.3
ABID97_RS04670 +0.5
ABID97_RS05865 +0.2
ABID97_RS05900 -0.4
ABID97_RS05990 +0.0
ABID97_RS06010 +0.2
ABID97_RS07755 +0.1
ABID97_RS10620 N.D.
ABID97_RS15740 +0.1
ABID97_RS17010 +0.2
ABID97_RS17470 -0.2
ABID97_RS18490 -0.7
ABID97_RS18600 +0.4
ABID97_RS18605 N.D.
ABID97_RS18635 +0.6
ABID97_RS20990 +0.4
ABID97_RS22770 +0.5
ABID97_RS24015 +0.5
ABID97_RS24805 -0.4
ABID97_RS26735 N.D.
ABID97_RS27490 -0.1
ABID97_RS27535 -0.3
ABID97_RS27555 +0.5
ABID97_RS27620 N.D.
ABID97_RS28260 N.D.
ABID97_RS28410 N.D.
ABID97_RS29050 +0.2
crotonyl-CoA[cytosol] + 2 NADH[cytosol] + 2 an oxidized ferredoxin [iron-sulfur] cluster[cytosol]→butanoyl-CoA[cytosol] + 2 NAD+[cytosol] + 2 a reduced ferredoxin [iron-sulfur] cluster[cytosol] (EC 1.3.1.109)
No genes
Butanal dehydrogenase (in reverse):
butanoyl-CoA + NAD(P)H + H+→1-butanal + coenzyme A + NAD(P)+ (EC 1.2.1.57)
No genes
Alcohol dehydrogenase (NADP(+)) (in reverse):
1-butanal + NADPH + H+→butan-1-ol + NADP+ (EC 1.1.1.2)
No genes
1-butanal + NADH + H+→butan-1-ol + NAD+
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information