| Reactions and Genes | Doxycycline hyclate 0.001 mg/ml |
|---|
| remove |
| a mature peptidoglycan (meso-DAP containing)→a mature peptidoglycan (meso-DAP containing) + GlcNAc-1,6-anhMurNAc-L-Ala-γ-D-Glu-meso-DAP-D-Ala (EC 4.2.2.f) |
| b0211 (mltD) | +0.1 |
| b1193 (mltE) | N.D. |
| b2558 (mltF) | -1.1 |
| b2701 (mltB) | +0.0 |
| b2813 (mltA) | +0.2 |
| b2963 (mltC) | +0.0 |
| b4392 (slt) | +0.2 |
| GlcNAc-1,6-anhMurNAc-L-Ala-γ-D-Glu-meso-DAP-D-Ala[out] + H+[out]→GlcNAc-1,6-anhMurNAc-L-Ala-γ-D-Glu-meso-DAP-D-Ala[in] + H+[in] |
| b0433 (ampG) | -0.1 |
N-acetylmuramoyl-L-alanine amidase:
GlcNAc-1,6-anhMurNAc-L-Ala-γ-D-Glu-meso-DAP-D-Ala + H2O→N-acetyl-β-D-glucosamine-1,6-anhydro-N-acetyl-β-D-muramate + L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanine (EC 3.5.1.28) |
| b0110 (ampD) | +0.6 |
| b0867 (ybjR) | -0.1 |
| b2435 (amiA) | -0.1 |
| b2817 (b2817) | -0.2 |
| b4169 (amiB) | +0.2 |
Beta-N-acetylhexosaminidase:
N-acetyl-β-D-glucosamine-1,6-anhydro-N-acetyl-β-D-muramate + H2O→1,6-anhydro-N-acetyl-β-D-muramate + N-acetyl-D-glucosamine (EC 3.2.1.52) |
| b1107 (nagZ) | -0.5 |
Muramoyltetrapeptide carboxypeptidase:
L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanine + H2O→L-alanyl-γ-D-glutamyl-meso-diaminopimelate + D-alanine (EC 3.4.17.13) |
| b1192 (ldcA) | +0.5 |
| 1,6-anhydro-N-acetyl-β-D-muramate + ATP + H2O→N-acetyl-D-muramate 6-phosphate + ADP + H+ (EC 2.7.1.170) |
| b1640 (ydhH) | -0.7 |
| N-acetyl-D-muramate 6-phosphate + H2O→N-acetyl-D-muramate + phosphate (EC 3.1.3.105) |
| No genes |
| N-acetyl-D-muramate + ATP→N-acetyl-α-D-muramate 1-phosphate + ADP + H+ (EC 2.7.1.221) |
| No genes |
| N-acetyl-α-D-muramate 1-phosphate + H+ + UDP→UDP-N-acetyl-α-D-muramate + phosphate (EC 2.7.7.99) |
| No genes |
| L-alanyl-γ-D-glutamyl-meso-diaminopimelate + UDP-N-acetyl-α-D-muramate + ATP→UDP-MurNAc-L-Ala-γ-D-Glu-meso-DAP + ADP + H+ + phosphate (EC 6.3.2.45) |
| b4233 (mpl) | -0.1 |
Links:
Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information