MetaCyc Pathway: heme b biosynthesis II (oxygen-independent) in Escherichia coli BW25113

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Reactions and Genes Chloride 750 mM
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Uroporphyrinogen decarboxylase:
uroporphyrinogen-III + 4 H+→coproporphyrinogen III + 4 CO2 (EC 4.1.1.37)
b3997 (hemE) N.D.
coproporphyrinogen III + 2 S-adenosyl-L-methionine→protoporphyrinogen IX + 2 CO2 + 2 5'-deoxyadenosine + 2 L-methionine (EC 1.3.98.3)
b3867 (hemN) -0.3
protoporphyrinogen IX[in] + 3 a menaquinone→protoporphyrin IX[in] + 3 a menaquinol (EC 1.3.5.3)
b3850 (hemG) N.D.
protoporphyrin IX + Fe2+→protoheme + 2 H+ (EC 4.98.1.1)
b0475 (hemH) N.D.
b1019 (ycdB) +0.4
b2431 (b2431) -2.1

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information