MetaCyc Pathway: valproate β-oxidation in Pseudomonas simiae WCS417

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Reactions and Genes LB_noSalt with Chloride 1100 mM
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Butyrate--CoA ligase:
valproate + ATP + coenzyme A→valproyl-CoA + AMP + diphosphate (EC 6.2.1.2)
No genes
valproyl-CoA + an oxidized electron-transfer flavoprotein + H+→(2E)-2-propylpent-2-enoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.5)
PS417_13840 +0.1
PS417_13850 +0.1
Enoyl-CoA hydratase (in reverse):
(2E)-2-propylpent-2-enoyl-CoA + H2O→(3S)-3-hydroxy-2-propylpentanoyl-CoA (EC 4.2.1.17)
PS417_07030 +0.2
PS417_07575 -0.6
PS417_08535 -0.4
PS417_10680 -0.3
PS417_11445 -2.2
PS417_12870 -0.2
PS417_13835 -0.2
PS417_13845 N.D.
PS417_21195 +0.0
PS417_21215 -0.0
PS417_22625 -0.1
3-hydroxyacyl-CoA dehydrogenase:
(3S)-3-hydroxy-2-propylpentanoyl-CoA + NAD+→3-oxo-2-propylpentanoyl-CoA + NADH + H+ (EC 1.1.1.35)
PS417_07575 -0.6
PS417_21215 -0.0
PS417_26285 -0.1
Acetyl-CoA C-acyltransferase (in reverse):
3-oxo-2-propylpentanoyl-CoA + coenzyme A→pentanoyl-CoA + propanoyl-CoA (EC 2.3.1.16)
PS417_06710 +0.0
PS417_07580 N.D.
PS417_10515 -0.0
PS417_13855 -0.4
PS417_15175 N.D.
PS417_19210 -0.1
PS417_21220 -0.2
PS417_03145 +0.0
pentanoyl-CoA + an oxidized electron-transfer flavoprotein + H+→(2E)-pent-2-enoyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.1)
PS417_02170 -0.1
(2E)-pent-2-enoyl-CoA + H2O→(3S)-3-hydroxypentanoyl-CoA
No genes
3-hydroxyacyl-CoA dehydrogenase:
(3S)-3-hydroxypentanoyl-CoA + NAD+→3-oxopentanoyl-CoA + NADH + H+ (EC 1.1.1.35)
PS417_07575 -0.6
PS417_21215 -0.0
PS417_26285 -0.1
Acetyl-CoA C-acyltransferase (in reverse):
3-oxopentanoyl-CoA + coenzyme A→propanoyl-CoA + acetyl-CoA (EC 2.3.1.16; 2.3.1.9)
PS417_06710 +0.0
PS417_07580 N.D.
PS417_10515 -0.0
PS417_13855 -0.4
PS417_15175 N.D.
PS417_19210 -0.1
PS417_21220 -0.2
PS417_03145 +0.0

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information