MetaCyc Pathway: superpathway of L-arginine and L-ornithine degradation in Pseudomonas putida KT2440

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Reactions and Genes Caprolactam (N)
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Arginine decarboxylase:
L-arginine + H+→agmatine + CO2 (EC 4.1.1.19)
PP_0567 -0.3
PP_0864 -0.1
Ornithine decarboxylase:
L-ornithine + H+→putrescine + CO2 (EC 4.1.1.17)
PP_0864 -0.1
Agmatinase:
agmatine + H2O→putrescine + urea (EC 3.5.3.11)
PP_2196 -0.1
PP_4523 -0.0
Putrescine aminotransferase:
putrescine + 2-oxoglutarate→4-aminobutanal + L-glutamate (EC 2.6.1.82)
No genes
Glutamate--putrescine ligase:
putrescine + ATP + L-glutamate→γ-glutamyl-L-putrescine + ADP + H+ + phosphate (EC 6.3.1.11)
PP_5299 -0.1
Aminobutyraldehyde dehydrogenase:
4-aminobutanal + NAD+ + H2O→4-aminobutanoate + NADH + 2 H+ (EC 1.2.1.19)
PP_0545 -0.0
PP_0665 +0.0
PP_0708 -0.1
PP_1481 +0.1
PP_1948 -0.0
PP_2487 -0.1
PP_2589 +0.1
PP_2680 +0.1
PP_2801 +0.1
PP_3463 +0.1
PP_3646 +0.0
PP_5278 -0.5
PP_5372 -0.1
4-aminobutanal→1-pyrroline + H2O (spontaneous)
No genes
γ-glutamyl-L-putrescine + dioxygen + H2O→4-(γ-L-glutamylamino)butanal + ammonium + hydrogen peroxide (EC 1.4.3.M3)
PP_2448 +0.0
PP_3146 -0.1
4-(γ-L-glutamylamino)butanal + NAD(P)+ + H2O→4-(γ-L-glutamylamino)butanoate + NAD(P)H + 2 H+ (EC 1.2.1.99)
No genes
Gamma-glutamyl-gamma-aminobutyrate hydrolase:
4-(γ-L-glutamylamino)butanoate + H2O→4-aminobutanoate + L-glutamate (EC 3.5.1.94)
PP_2179 +1.6
PP_3598 +0.1
PP_5298 +0.1
4-aminobutyrate transaminase:
4-aminobutanoate + 2-oxoglutarate→succinate semialdehyde + L-glutamate (EC 2.6.1.19)
PP_0214 -1.5
PP_3361 -0.2
PP_4108 +0.4
PP_4421 -0.0
Succinate-semialdehyde dehydrogenase:
succinate semialdehyde + NAD+ + H2O→succinate + NADH + 2 H+ (EC 1.2.1.24)
PP_2488 +0.1
PP_3151 -0.0
succinate semialdehyde + NADP+ + H2O→succinate + NADPH + 2 H+ (EC 1.2.1.79)
PP_2488 +0.1
PP_4422 +3.3

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information