MetaCyc Pathway: superpathway of L-citrulline metabolism in Pseudomonas putida KT2440

Add experiment(s):


Reactions and Genes 3-aminobutyric (N)
remove
Glutamate synthase (NADPH):
L-glutamine + H2O→L-glutamate + ammonia + H+ (EC 1.4.1.13; 1.4.1.14; 1.4.7.1; 2.6.1.85; 3.5.1.2; 3.5.1.38; 4.1.3.27; 4.3.2.10; 4.3.3.6; 6.3.4.2; 6.3.5.13; 6.3.5.2; 6.3.5.4; 6.3.5.5; 6.3.5.6; 6.3.5.7)
PP_0269 -0.1
PP_0417 -4.1
PP_0420 -4.4
PP_0511 +0.0
PP_0613 +0.0
PP_0727 -0.0
PP_0930 N.D.
PP_0931 N.D.
PP_0932 N.D.
PP_0991 +0.2
PP_1032 N.D.
PP_1060 +0.1
PP_1374 -0.2
PP_1460 +0.2
PP_1610 N.D.
PP_1691 -0.4
PP_1750 -0.1
PP_1842 +0.1
PP_2323 -0.1
PP_2329 +0.0
PP_2447 -0.0
PP_2453 -0.1
PP_3464 -0.2
PP_3598 +0.2
PP_4037 -1.5
PP_4723 -4.2
PP_4724 -4.1
PP_5075 -4.2
PP_5076 -4.0
Carbamoyl-phosphate synthase (ammonia):
ammonium + 2 ATP + hydrogen carbonate→carbamoyl phosphate + 2 ADP + 2 H+ + phosphate (EC 6.3.4.16)
No genes
L-proline[in] + an electron-transfer quinone→(S)-1-pyrroline-5-carboxylate[in] + an electron-transfer quinol + H+[in] (EC 1.5.5.2)
PP_4947 -0.9
Glutamate 5-kinase:
L-glutamate + ATP→γ-L-glutamyl 5-phosphate + ADP (EC 2.7.2.11)
PP_0691 -1.8
(S)-1-pyrroline-5-carboxylate + H+ + H2O→L-glutamate 5-semialdehyde (spontaneous)
No genes
Glutamate-5-semialdehyde dehydrogenase (in reverse):
γ-L-glutamyl 5-phosphate + NADPH + H+→L-glutamate 5-semialdehyde + NADP+ + phosphate (EC 1.2.1.41)
PP_4811 -0.2
Ornithine aminotransferase (in reverse):
L-glutamate + L-glutamate 5-semialdehyde→L-ornithine + 2-oxoglutarate (EC 2.6.1.13)
PP_4481 -0.2
Ornithine carbamoyltransferase:
L-ornithine + carbamoyl phosphate→L-citrulline + H+ + phosphate (EC 2.1.3.3)
PP_1000 +0.2
PP_1079 -4.2
Argininosuccinate synthase:
L-citrulline + ATP + L-aspartate→L-arginino-succinate + AMP + diphosphate + H+ (EC 6.3.4.5)
PP_1088 -3.6
Argininosuccinate lyase:
L-arginino-succinate→L-arginine + fumarate (EC 4.3.2.1)
PP_0184 -4.7
PP_0730 +0.0
Arginase:
L-arginine + H2O→L-ornithine + urea (EC 3.5.3.1)
No genes
Nitric-oxide synthase:
2 L-arginine + 3 NADPH + 4 dioxygen + H+→2 L-citrulline + 3 NADP+ + 2 nitric oxide + 4 H2O (EC 1.14.13.39)
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information