MetaCyc Pathway: siroheme biosynthesis in Paraburkholderia sabiae LMG 24235

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Reactions and Genes Fumaric (C)
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Uroporphyrinogen-III C-methyltransferase:
uroporphyrinogen-III + S-adenosyl-L-methionine→precorrin-1 + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.107)
QEN71_RS08705 -0.1
QEN71_RS13600 +0.0
QEN71_RS24945 -3.0
QEN71_RS25230 -1.5
Uroporphyrinogen-III C-methyltransferase:
precorrin-1 + S-adenosyl-L-methionine→precorrin-2 + S-adenosyl-L-homocysteine (EC 2.1.1.107)
QEN71_RS08705 -0.1
QEN71_RS13600 +0.0
QEN71_RS24945 -3.0
QEN71_RS25230 -1.5
Precorrin-2 dehydrogenase:
precorrin-2 + NAD+→sirohydrochlorin + NADH + 2 H+ (EC 1.3.1.76)
QEN71_RS08705 -0.1
QEN71_RS13600 +0.0
QEN71_RS25220 -3.8
QEN71_RS25230 -1.5
Sirohydrochlorin ferrochelatase:
sirohydrochlorin + Fe2+→siroheme + 2 H+ (EC 4.99.1.4)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information