MetaCyc Pathway: benzoate biosynthesis I (CoA-dependent, β-oxidative) in Paraburkholderia sabiae LMG 24235

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Reactions and Genes L-Leucine (C)
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Phenylalanine ammonia-lyase:
L-phenylalanine→trans-cinnamate + ammonium (EC 4.3.1.24; 4.3.1.25; 5.4.3.10)
No genes
trans-cinnamate + ATP + coenzyme A→(E)-cinnamoyl-CoA + AMP + diphosphate
No genes
Enoyl-CoA hydratase (in reverse):
(E)-cinnamoyl-CoA + H2O→(S)-3-hydroxy-3-phenylpropanoyl-CoA (EC 4.2.1.17)
QEN71_RS01230 +0.1
QEN71_RS02065 +0.0
QEN71_RS02075 -0.2
QEN71_RS04150 -0.1
QEN71_RS05365 -0.0
QEN71_RS06625 -0.2
QEN71_RS08225 N.D.
QEN71_RS10900 -0.0
QEN71_RS12380 -1.1
QEN71_RS12385 -0.6
QEN71_RS15965 +0.1
QEN71_RS16060 +0.2
QEN71_RS19420 -1.4
QEN71_RS19500 -0.2
QEN71_RS21890 +0.2
QEN71_RS22700 +0.2
QEN71_RS24020 +0.2
QEN71_RS24025 -0.1
QEN71_RS26140 -0.3
QEN71_RS27495 +0.2
QEN71_RS27510 +0.2
QEN71_RS29945 +0.0
QEN71_RS30540 +0.7
QEN71_RS30550 N.D.
QEN71_RS30645 +0.4
QEN71_RS32940 -0.2
QEN71_RS33220 -0.1
QEN71_RS35840 -0.1
QEN71_RS38515 N.D.
QEN71_RS39250 -0.1
QEN71_RS39410 -0.1
QEN71_RS39560 +0.2
3-hydroxyacyl-CoA dehydrogenase:
(S)-3-hydroxy-3-phenylpropanoyl-CoA + NAD+→3-oxo-3-phenylpropanoyl-CoA + NADH + H+ (EC 1.1.1.35)
QEN71_RS02065 +0.0
QEN71_RS21890 +0.2
QEN71_RS24020 +0.2
QEN71_RS29945 +0.0
QEN71_RS37855 N.D.
Acetyl-CoA C-acyltransferase (in reverse):
3-oxo-3-phenylpropanoyl-CoA + coenzyme A→benzoyl-CoA + acetyl-CoA (EC 2.3.1.16)
QEN71_RS01125 +0.1
QEN71_RS02070 -0.1
QEN71_RS14170 +0.1
QEN71_RS15980 -0.1
QEN71_RS18320 -1.1
QEN71_RS18730 +0.0
QEN71_RS21880 +0.1
QEN71_RS22175 +0.0
QEN71_RS22200 -1.3
QEN71_RS22970 -0.1
QEN71_RS27505 -0.0
benzoyl-CoA + H2O→benzoate + coenzyme A + H+
QEN71_RS16070 N.D.
benzoyl-CoA + benzyl alcohol→benzyl benzoate + coenzyme A (EC 2.3.1.196)
No genes
benzyl benzoate + H2O→benzoate + benzyl alcohol + H+
No genes
Benzoate--CoA ligase:
benzoate + ATP + coenzyme A→benzoyl-CoA + AMP + diphosphate (EC 6.2.1.25)
QEN71_RS05350 -0.1

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information