MetaCyc Pathway: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass in Paraburkholderia sabiae LMG 24235

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Reactions and Genes L-Leucine (C)
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D-glucopyranose[out] + an [HPr protein]-Nπ-phospho-L-histidine[in]→D-glucopyranose 6-phosphate[in] + an [HPr]-L-histidine[in] (EC 2.7.1.199)
No genes
Glucose-6-phosphate isomerase:
α-D-glucose 6-phosphate→β-D-fructofuranose 6-phosphate (EC 5.3.1.9)
QEN71_RS21935 -0.8
6-phosphofructokinase:
β-D-fructofuranose 6-phosphate + ATP→β-D-fructofuranose 1,6-bisphosphate + ADP + H+ (EC 2.7.1.11)
No genes
Fructose-bisphosphate aldolase:
β-D-fructofuranose 1,6-bisphosphate→glycerone phosphate + D-glyceraldehyde 3-phosphate (EC 4.1.2.13)
QEN71_RS02435 N.D.
QEN71_RS13015 +0.0
Fructose-bisphosphatase:
β-D-fructofuranose 1,6-bisphosphate + H2O→β-D-fructofuranose 6-phosphate + phosphate (EC 3.1.3.11)
QEN71_RS03770 N.D.
QEN71_RS32775 +0.0
QEN71_RS34115 +0.3
Triose-phosphate isomerase (in reverse):
glycerone phosphate→D-glyceraldehyde 3-phosphate (EC 5.3.1.1)
QEN71_RS24165 -3.6
QEN71_RS41515 +0.1
Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating):
D-glyceraldehyde 3-phosphate + NAD+ + phosphate→3-phospho-D-glyceroyl phosphate + NADH + H+ (EC 1.2.1.12)
QEN71_RS27005 -3.8
Phosphoglycerate kinase (in reverse):
3-phospho-D-glyceroyl phosphate + ADP→3-phospho-D-glycerate + ATP (EC 2.7.2.3)
QEN71_RS02425 -2.8
3-phospho-D-glycerate→2-phospho-D-glycerate (EC 5.4.2.12)
QEN71_RS01445 -4.3
3-phospho-D-glycerate→2-phospho-D-glycerate (EC 5.4.2.11)
QEN71_RS01445 -4.3
Phosphopyruvate hydratase:
2-phospho-D-glycerate→phosphoenolpyruvate + H2O (EC 4.2.1.11)
QEN71_RS05880 N.D.
QEN71_RS41510 -0.1
Pyruvate kinase (in reverse):
phosphoenolpyruvate + ADP + H+→pyruvate + ATP (EC 2.7.1.40)
QEN71_RS02430 +0.1
QEN71_RS12195 +0.1
QEN71_RS41440 +0.1
Pyruvate, water dikinase:
pyruvate + ATP + H2O→phosphoenolpyruvate + AMP + 2 H+ + phosphate (EC 2.7.9.2)
QEN71_RS06505 +0.6
QEN71_RS07110 N.D.
pyruvate + coenzyme A + NAD+→acetyl-CoA + CO2 + NADH (EC 1.2.1.104)
QEN71_RS05730 N.D.
QEN71_RS23700 -0.1
QEN71_RS40215 -0.2
QEN71_RS40225 -0.1
Citrate (Si)-synthase:
acetyl-CoA + oxaloacetate + H2O→citrate + coenzyme A + H+ (EC 2.3.3.1; 2.3.3.16; 2.3.3.3)
QEN71_RS02900 +0.4
QEN71_RS11110 -0.0
QEN71_RS17600 -3.3
QEN71_RS38525 +0.2
QEN71_RS39030 +0.2
Malate synthase:
acetyl-CoA + glyoxylate + H2O→(S)-malate + coenzyme A + H+ (EC 2.3.3.9)
QEN71_RS06250 +0.2
QEN71_RS31820 -0.6
Aconitate hydratase:
citrate→cis-aconitate + H2O (EC 4.2.1.3)
QEN71_RS17535 +0.2
QEN71_RS19735 -0.2
QEN71_RS31060 -0.5
QEN71_RS41385 +0.0
Aconitate hydratase:
cis-aconitate + H2O→D-threo-isocitrate (EC 4.2.1.3)
QEN71_RS17535 +0.2
QEN71_RS19735 -0.2
QEN71_RS31060 -0.5
QEN71_RS41385 +0.0
Isocitrate lyase:
D-threo-isocitrate→glyoxylate + succinate (EC 4.1.3.1)
QEN71_RS06270 -3.3
Isocitrate dehydrogenase (NADP(+)):
D-threo-isocitrate + NADP+→2-oxoglutarate + CO2 + NADPH (EC 1.1.1.42)
QEN71_RS02980 -0.1
QEN71_RS09660 N.D.
2-oxoglutarate + coenzyme A + NAD+→succinyl-CoA + CO2 + NADH (EC 1.2.1.105)
No genes
Succinate--CoA ligase (ADP-forming) (in reverse):
succinyl-CoA + ADP + phosphate→succinate + ATP + coenzyme A (EC 6.2.1.5)
QEN71_RS02350 -0.6
QEN71_RS02355 -0.7
QEN71_RS20400 -0.1
QEN71_RS20405 -0.0
QEN71_RS33990 -1.3
QEN71_RS33995 -0.0
Succinate dehydrogenase (ubiquinone):
succinate[in] + an electron-transfer quinone→fumarate[in] + an electron-transfer quinol (EC 1.3.5.1)
QEN71_RS17585 N.D.
QEN71_RS17590 N.D.
QEN71_RS38665 N.D.
QEN71_RS38670 N.D.
Fumarate hydratase (in reverse):
fumarate + H2O→(S)-malate (EC 4.2.1.2)
QEN71_RS04360 -0.2
QEN71_RS11740 -0.1
QEN71_RS23780 +0.1
Malate dehydrogenase:
(S)-malate + NAD+→oxaloacetate + NADH + H+ (EC 1.1.1.37; 1.1.1.38)
QEN71_RS10905 +0.2
QEN71_RS17565 N.D.
QEN71_RS36375 +0.3
(S)-malate[in] + an electron-transfer quinone→oxaloacetate[in] + an electron-transfer quinol (EC 1.1.5.4)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information