MetaCyc Pathway: superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle in Paraburkholderia sabiae LMG 24235

Reactions and Genes	D-Sorbitol (C)
Diphosphate--fructose-6-phosphate 1-phosphotransferase: β-D-fructofuranose 6-phosphate + diphosphate→β-D-fructofuranose 1,6-bisphosphate + H+ + phosphate (EC 2.7.1.90)
No genes
6-phosphofructokinase: β-D-fructofuranose 6-phosphate + ATP→β-D-fructofuranose 1,6-bisphosphate + ADP + H+ (EC 2.7.1.11)
No genes
Fructose-bisphosphate aldolase: β-D-fructofuranose 1,6-bisphosphate→glycerone phosphate + D-glyceraldehyde 3-phosphate (EC 4.1.2.13)
QEN71_RS02435	N.D.
QEN71_RS13015	-0.1
Triose-phosphate isomerase (in reverse): glycerone phosphate→D-glyceraldehyde 3-phosphate (EC 5.3.1.1)
QEN71_RS24165	-2.3
QEN71_RS41515	+0.2
Glyceraldehyde-3-phosphate dehydrogenase (NADP(+)): D-glyceraldehyde 3-phosphate + NADP+ + H2O→3-phospho-D-glycerate + NADPH + 2 H+ (EC 1.2.1.9)
No genes
Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating): D-glyceraldehyde 3-phosphate + NAD+ + phosphate→3-phospho-D-glyceroyl phosphate + NADH + H+ (EC 1.2.1.12)
QEN71_RS27005	-4.5
Phosphoglycerate kinase (in reverse): 3-phospho-D-glyceroyl phosphate + ADP→3-phospho-D-glycerate + ATP (EC 2.7.2.3)
QEN71_RS02425	-1.4
3-phospho-D-glycerate→2-phospho-D-glycerate (EC 5.4.2.12)
QEN71_RS01445	-3.8
Phosphopyruvate hydratase: 2-phospho-D-glycerate→phosphoenolpyruvate + H2O (EC 4.2.1.11)
QEN71_RS05880	N.D.
QEN71_RS41510	+0.2
Pyruvate kinase (in reverse): phosphoenolpyruvate + ADP + H+→pyruvate + ATP (EC 2.7.1.40)
QEN71_RS02430	-1.3
QEN71_RS12195	-0.1
QEN71_RS41440	-0.2
pyruvate + a [pyruvate dehydrogenase E2 protein] N6-lipoyl-L-lysine + H+→a [pyruvate dehydrogenase E2 protein] N6-S-acetyldihydrolipoyl-L-lysine + CO2 (EC 1.2.1.104; 1.2.4.1)
QEN71_RS05725	N.D.
QEN71_RS14130	+0.2
QEN71_RS14135	-0.1
QEN71_RS23700	+0.1
QEN71_RS40225	-0.2
a [pyruvate dehydrogenase E2 protein] N6-S-acetyldihydrolipoyl-L-lysine + coenzyme A→acetyl-CoA + a [pyruvate dehydrogenase E2 protein] N6-dihydrolipoyl-L-lysine (EC 1.2.1.104; 2.3.1.12)
QEN71_RS05730	N.D.
QEN71_RS14125	+0.1
QEN71_RS40215	-0.4
Citrate (Si)-synthase: oxaloacetate + acetyl-CoA + H2O→citrate + coenzyme A + H+ (EC 2.3.3.1; 2.3.3.16; 2.3.3.3)
QEN71_RS02900	+0.2
QEN71_RS11110	+0.2
QEN71_RS17600	-3.2
QEN71_RS38525	-0.0
QEN71_RS39030	-0.0
a [pyruvate dehydrogenase E2 protein] N6-dihydrolipoyl-L-lysine + NAD+→a [pyruvate dehydrogenase E2 protein] N6-lipoyl-L-lysine + NADH + H+ (EC 1.2.1.104; 1.8.1.4)
QEN71_RS05735	-0.2
QEN71_RS10420	-0.0
QEN71_RS23050	N.D.
QEN71_RS40210	+0.0
Aconitate hydratase: citrate→cis-aconitate + H2O (EC 4.2.1.3)
QEN71_RS17535	+0.5
QEN71_RS19735	-0.3
QEN71_RS31060	-0.4
QEN71_RS41385	+0.0
Aconitate hydratase: cis-aconitate + H2O→D-threo-isocitrate (EC 4.2.1.3)
QEN71_RS17535	+0.5
QEN71_RS19735	-0.3
QEN71_RS31060	-0.4
QEN71_RS41385	+0.0
Isocitrate--homoisocitrate dehydrogenase: D-threo-isocitrate + NAD+→2-oxoglutarate + CO2 + NADH (EC 1.1.1.286; 1.1.1.41)
No genes
2-oxoglutarate + coenzyme A + NAD+→succinyl-CoA + CO2 + NADH (EC 1.2.1.105)
No genes
Succinate--CoA ligase (ADP-forming) (in reverse): succinyl-CoA + ADP + phosphate→succinate + ATP + coenzyme A (EC 6.2.1.5)
QEN71_RS02350	-4.0
QEN71_RS02355	-4.3
QEN71_RS20400	-0.1
QEN71_RS20405	-0.2
QEN71_RS33990	+0.5
QEN71_RS33995	+0.0
Succinate dehydrogenase (ubiquinone): succinate[in] + an electron-transfer quinone→fumarate[in] + an electron-transfer quinol (EC 1.3.5.1)
QEN71_RS17585	N.D.
QEN71_RS17590	N.D.
QEN71_RS38665	N.D.
QEN71_RS38670	N.D.
Fumarate hydratase (in reverse): fumarate + H2O→(S)-malate (EC 4.2.1.2)
QEN71_RS04360	-0.0
QEN71_RS11740	-0.0
QEN71_RS23780	+0.0
Malate dehydrogenase: (S)-malate + NAD+→oxaloacetate + NADH + H+ (EC 1.1.1.37; 1.1.1.38)
QEN71_RS10905	+0.1
QEN71_RS17565	N.D.
QEN71_RS36375	+0.3

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information