MetaCyc Pathway: superpathway of L-threonine metabolism in Paraburkholderia sabiae LMG 24235

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Reactions and Genes L-Leucine (C)
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Threonine ammonia-lyase:
L-threonine→(Z)-2-aminobutenoate + H2O (EC 4.3.1.19)
QEN71_RS01985 -3.4
QEN71_RS09705 -0.7
QEN71_RS14265 -0.2
QEN71_RS14710 -0.3
QEN71_RS22075 -0.1
QEN71_RS36235 +0.1
QEN71_RS41370 -0.0
L-threonine + ATP→L-threonine 3-O-phosphate + ADP + H+ (EC 2.7.1.177)
QEN71_RS40455 -0.2
L-threonine 3-dehydrogenase:
L-threonine + NAD+→L-2-amino-3-oxobutanoate + NADH + H+ (EC 1.1.1.103)
QEN71_RS16540 -0.2
L-threonine→acetaldehyde + glycine (EC 4.1.2.48; 4.1.2.5)
QEN71_RS05000 -1.2
QEN71_RS14320 +0.0
Threonine-phosphate decarboxylase:
L-threonine 3-O-phosphate + H+→(R)-1-amino-2-propanol O-2-phosphate + CO2 (EC 4.1.1.81)
QEN71_RS25110 -0.2
Acetaldehyde dehydrogenase (acetylating):
acetaldehyde + coenzyme A + NAD+→acetyl-CoA + NADH + H+ (EC 1.2.1.10)
No genes
Glycine C-acetyltransferase (in reverse):
L-2-amino-3-oxobutanoate + coenzyme A→glycine + acetyl-CoA (EC 2.3.1.29)
QEN71_RS16535 -0.3
1-aminocyclopropane-1-carboxylate deaminase:
(Z)-2-aminobutenoate→2-iminobutanoate (spontaneous) (EC 3.5.99.7; 4.3.1.19; 4.4.1.1; 4.4.1.11; 4.4.1.2)
QEN71_RS01985 -3.4
QEN71_RS09705 -0.7
QEN71_RS09955 -0.3
QEN71_RS14265 -0.2
QEN71_RS14710 -0.3
QEN71_RS22075 -0.1
QEN71_RS36235 +0.1
QEN71_RS36520 N.D.
QEN71_RS38310 +0.2
QEN71_RS41370 -0.0
L-threonine 3-dehydrogenase:
L-2-amino-3-oxobutanoate + H+→aminoacetone + CO2 (spontaneous) (EC 1.1.1.103; 1.1.1.381)
QEN71_RS16540 -0.2
Primary-amine oxidase:
aminoacetone + dioxygen + H2O→methylglyoxal + ammonium + hydrogen peroxide (EC 1.4.3.21)
No genes
2-iminobutanoate + H2O→2-oxobutanoate + ammonium (spontaneous) (EC 3.5.99.10; 3.5.99.7; 4.3.1.19; 4.4.1.1; 4.4.1.11; 4.4.1.2)
QEN71_RS01985 -3.4
QEN71_RS09705 -0.7
QEN71_RS09955 -0.3
QEN71_RS14265 -0.2
QEN71_RS14710 -0.3
QEN71_RS22075 -0.1
QEN71_RS36235 +0.1
QEN71_RS36520 N.D.
QEN71_RS38310 +0.2
QEN71_RS41370 -0.0
Acetolactate synthase:
2-oxobutanoate + H+ + pyruvate→(S)-2-aceto-2-hydroxybutanoate + CO2 (EC 2.2.1.6)
QEN71_RS16935 +0.2
QEN71_RS24220 -1.0
QEN71_RS24225 -3.5
QEN71_RS24495 +0.0
QEN71_RS29230 -0.0
QEN71_RS31350 +0.0
QEN71_RS38255 -0.4
QEN71_RS40220 -0.2
Formate C-acetyltransferase (in reverse):
2-oxobutanoate + coenzyme A→propanoyl-CoA + formate (EC 2.3.1.54)
No genes
Ketol-acid reductoisomerase (in reverse):
(S)-2-aceto-2-hydroxybutanoate + NADPH + H+→(R)-2,3-dihydroxy-3-methylpentanoate + NADP+ (EC 1.1.1.86)
QEN71_RS24215 -3.6
QEN71_RS35995 +0.0
propanoyl-CoA + phosphate→propanoyl phosphate + coenzyme A (EC 2.3.1.222)
QEN71_RS13530 -0.3
Dihydroxy-acid dehydratase:
(R)-2,3-dihydroxy-3-methylpentanoate→(3S)-3-methyl-2-oxopentanoate + H2O (EC 4.2.1.9)
QEN71_RS10105 -0.3
QEN71_RS12580 +0.0
QEN71_RS13580 -0.3
QEN71_RS16810 -0.1
QEN71_RS18040 -0.2
QEN71_RS21095 +0.1
QEN71_RS25185 +0.0
QEN71_RS35715 -0.1
QEN71_RS38760 -0.1
Acetate kinase (in reverse):
propanoyl phosphate + ADP→propanoate + ATP (EC 2.7.2.1; 2.7.2.14; 2.7.2.15; 2.7.2.7)
QEN71_RS13535 -0.1
Branched-chain-amino-acid transaminase (in reverse):
(3S)-3-methyl-2-oxopentanoate + L-glutamate→L-isoleucine + 2-oxoglutarate (EC 2.6.1.42)
QEN71_RS02410 -1.1

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information