MetaCyc Pathway: adipate biosynthesis in Paraburkholderia sabiae LMG 24235

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Reactions and Genes L-Leucine (C)
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3-oxoadipyl-CoA thiolase:
acetyl-CoA + succinyl-CoA→3-oxoadipoyl-CoA + coenzyme A (EC 2.3.1.174)
QEN71_RS14170 -0.1
QEN71_RS27505 +0.1
3-hydroxyacyl-CoA dehydrogenase (in reverse):
3-oxoadipoyl-CoA + NADH + H+→(3S)-hydroxyadipyl-CoA + NAD+ (EC 1.1.1.35)
QEN71_RS02065 +0.1
QEN71_RS21890 +0.1
QEN71_RS24020 +0.1
QEN71_RS29945 +0.0
QEN71_RS37855 N.D.
Enoyl-CoA hydratase:
(3S)-hydroxyadipyl-CoA→(2E)-5-carboxy-2-pentenoyl-CoA + H2O (EC 4.2.1.17)
QEN71_RS01230 +0.3
QEN71_RS02065 +0.1
QEN71_RS02075 -0.3
QEN71_RS04150 -0.1
QEN71_RS05365 +0.1
QEN71_RS06625 -0.2
QEN71_RS08225 N.D.
QEN71_RS10900 +0.1
QEN71_RS12380 -1.2
QEN71_RS12385 -0.6
QEN71_RS15965 -0.0
QEN71_RS16060 +0.1
QEN71_RS19420 -1.6
QEN71_RS19500 -0.2
QEN71_RS21890 +0.1
QEN71_RS22700 +0.0
QEN71_RS24020 +0.1
QEN71_RS24025 -0.7
QEN71_RS26140 +0.9
QEN71_RS27495 +0.2
QEN71_RS27510 +0.6
QEN71_RS29945 +0.0
QEN71_RS30540 -0.8
QEN71_RS30550 N.D.
QEN71_RS30645 +0.4
QEN71_RS32940 +0.3
QEN71_RS33220 -0.0
QEN71_RS35840 -0.5
QEN71_RS38515 N.D.
QEN71_RS39250 -0.0
QEN71_RS39410 -0.3
QEN71_RS39560 +0.1
(2E)-5-carboxy-2-pentenoyl-CoA + FADH2→adipoyl-CoA + FAD + H+
No genes
Succinate--CoA ligase (ADP-forming) (in reverse):
adipoyl-CoA + ADP + phosphate→adipate + ATP + coenzyme A (EC 6.2.1.5)
QEN71_RS02350 -0.7
QEN71_RS02355 -0.7
QEN71_RS18090 -0.1
QEN71_RS18095 -0.1
QEN71_RS20400 +0.1
QEN71_RS20405 +0.1
QEN71_RS33990 -0.1
QEN71_RS33995 -0.1

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information