MetaCyc Pathway: superpathway of L-lysine, L-threonine and L-methionine biosynthesis I in Paraburkholderia sabiae LMG 24235

Add experiment(s):


Reactions and Genes Plant=Phaseolus_vulgaris; PlantTreatment=None; Sample=rhizosphere; GrowthSubstrate=0.5X_MS_agar; Collection=outgrowth_LB; Time=14_days
remove
Aspartate transaminase (in reverse):
oxaloacetate + L-glutamate→L-aspartate + 2-oxoglutarate
(EC 2.6.1.1)
QEN71_RS00075 +0.1
QEN71_RS02890 -0.0
QEN71_RS03175 +0.1
QEN71_RS03275 +0.1
QEN71_RS06560 +0.2
QEN71_RS08880 +0.1
QEN71_RS10500 +0.1
QEN71_RS12205 -0.2
QEN71_RS12215 -0.5
QEN71_RS13030 -0.0
QEN71_RS17025 -0.0
QEN71_RS18160 -0.2
QEN71_RS18375 -0.4
QEN71_RS20720 +0.2
QEN71_RS21505 +0.2
QEN71_RS22410 -1.9
QEN71_RS23125 +0.1
QEN71_RS23470 -0.1
QEN71_RS24010 +0.0
QEN71_RS24645 -0.1
QEN71_RS30710 -0.0
QEN71_RS31640 +0.1
QEN71_RS32300 -0.4
QEN71_RS36905 +0.3
QEN71_RS38860 +0.1
QEN71_RS38900 +0.1
QEN71_RS38970 +0.4
Aspartate kinase:
L-aspartate + ATP→L-aspartyl-4-phosphate + ADP
(EC 2.7.2.4)
QEN71_RS06150 -5.0
Aspartate-semialdehyde dehydrogenase (in reverse):
L-aspartyl-4-phosphate + NADPH + H+→L-aspartate 4-semialdehyde + NADP+ + phosphate
(EC 1.2.1.11)
QEN71_RS17625 N.D.
L-aspartate 4-semialdehyde + pyruvate→(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H+ + H2O (EC 4.3.3.7)
QEN71_RS05940 N.D.
QEN71_RS11050 +0.2
QEN71_RS20640 -0.3
QEN71_RS30495 -0.2
QEN71_RS34275 -0.3
QEN71_RS35845 -0.8
QEN71_RS35895 +0.2
QEN71_RS39630 -0.4
QEN71_RS41290 +0.5
Homoserine dehydrogenase (in reverse):
L-aspartate 4-semialdehyde + NAD(P)H + H+→L-homoserine + NAD(P)+
(EC 1.1.1.3)
QEN71_RS22405 -6.4
Homoserine kinase:
L-homoserine + ATP→O-phospho-L-homoserine + ADP + H+
(EC 2.7.1.39)
QEN71_RS17850 -5.3
Homoserine O-succinyltransferase:
L-homoserine + succinyl-CoA→O-succinyl-L-homoserine + coenzyme A
(EC 2.3.1.46)
QEN71_RS42530 -0.5
(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+→(S)-2,3,4,5-tetrahydrodipicolinate + NAD(P)+ + H2O (EC 1.17.1.8)
QEN71_RS26970 N.D.
Cystathionine gamma-synthase:
O-succinyl-L-homoserine + L-cysteine→L-cystathionine + H+ + succinate
(EC 2.5.1.48)
QEN71_RS05200 +0.2
QEN71_RS17685 +0.1
QEN71_RS38310 +0.0
QEN71_RS42510 +0.2
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase:
(S)-2,3,4,5-tetrahydrodipicolinate + succinyl-CoA + H2ON-succinyl-2-amino-6-ketopimelate + coenzyme A
(EC 2.3.1.117)
QEN71_RS06365 N.D.
Threonine synthase:
O-phospho-L-homoserine + H2O→L-threonine + phosphate
(EC 4.2.3.1)
QEN71_RS18575 -0.0
QEN71_RS22400 -5.2
QEN71_RS40245 N.D.
QEN71_RS40295 N.D.
QEN71_RS41235 +0.3
Cysteine-S-conjugate beta-lyase:
L-cystathionine + H2O→L-homocysteine + ammonium + pyruvate
(EC 4.4.1.13)
No genes
Succinyldiaminopimelate transaminase (in reverse):
N-succinyl-2-amino-6-ketopimelate + L-glutamateN-succinyl-L,L-2,6-diaminopimelate + 2-oxoglutarate
(EC 2.6.1.17)
QEN71_RS03130 -0.0
QEN71_RS04065 -3.1
QEN71_RS06370 -0.3
QEN71_RS23375 N.D.
5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase:
L-homocysteine + 5-methyltetrahydropteroyl tri-L-glutamate→L-methionine + tetrahydropteroyl tri-L-glutamate
(EC 2.1.1.14)
QEN71_RS19725 -0.8
Methionine synthase:
L-homocysteine + a 5-methyltetrahydrofolate→L-methionine + a tetrahydrofolate
(EC 2.1.1.13)
QEN71_RS01190 +0.0
QEN71_RS01195 -0.2
Succinyl-diaminopimelate desuccinylase:
N-succinyl-L,L-2,6-diaminopimelate + H2O→L,L-diaminopimelate + succinate
(EC 3.5.1.18)
QEN71_RS06355 -2.8
QEN71_RS22065 +0.1
Diaminopimelate epimerase:
L,L-diaminopimelate→meso-diaminopimelate
(EC 5.1.1.7)
QEN71_RS00365 N.D.
QEN71_RS03330 -1.7
QEN71_RS08005 -1.1
QEN71_RS25975 -0.1
Diaminopimelate decarboxylase:
meso-diaminopimelate + H+→L-lysine + CO2
(EC 4.1.1.20)
QEN71_RS28080 -4.6

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information