MetaCyc Pathway: superpathway of L-alanine fermentation (Stickland reaction) in Phocaeicola dorei CL03T12C01

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Reactions and Genes N-acetylneuraminic (C)
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Alanine transaminase:
L-alanine + 2-oxoglutarate→pyruvate + L-glutamate (EC 2.6.1.2)
No genes
D-lactate dehydrogenase (in reverse):
pyruvate + NADH + H+→(R)-lactate + NAD+ (EC 1.1.1.28)
ABI39_RS12465 +1.7
Pyruvate synthase:
pyruvate + coenzyme A + 2 an oxidized ferredoxin [iron-sulfur] cluster→acetyl-CoA + CO2 + H+ + 2 a reduced ferredoxin [iron-sulfur] cluster (EC 1.2.7.1)
ABI39_RS18745 -5.2
Propionate CoA-transferase:
(R)-lactate + propanoyl-CoA→(R)-lactoyl-CoA + propanoate (EC 2.8.3.1)
No genes
Phosphate acetyltransferase:
acetyl-CoA + phosphate→acetyl phosphate + coenzyme A (EC 2.3.1.8)
ABI39_RS02730 N.D.
Acetate kinase (in reverse):
acetyl phosphate + ADP→acetate + ATP (EC 2.7.2.1; 2.7.2.15)
ABI39_RS02735 N.D.
ABI39_RS14185 +0.2
Lactoyl-CoA dehydratase:
(R)-lactoyl-CoA→acryloyl-CoA + H2O (EC 4.2.1.54)
No genes
acryloyl-CoA + NADH + H+→propanoyl-CoA + NAD+ (EC 1.3.1.95)
No genes
Propionate CoA-transferase (in reverse):
propanoyl-CoA + acetate→propanoate + acetyl-CoA (EC 2.8.3.1)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information